NUDT16
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Official Full Name
methionyl aminopeptidase 1 -
Overview
Removes the amino-terminal methionine from nascent proteins. Required for normal progression through the cell cycle. -
Synonyms
METAP1;methionyl aminopeptidase 1;methionine aminopeptidase 1;KIAA0094;MAP1A;MetAP1A;Peptidase M;MAP 1;metAP 1;peptidase M 1;DKFZp781C0419
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Involved Pathway
NUDT16 involved in several pathways and played different roles in them. We selected most pathways NUDT16 participated on our site, such as Metabolism,Metabolism of nucleotides,Phosphate bond hydrolysis by NUDT proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUDT16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | ENPP1,APRT,POLR1A,NT5C3B,CANT1,PNP5A,PDE3A,RRM2,POLD4,NME5 |
| Metabolism | CYP2K6,FAM36A,HS3ST6,SCO1,CHKA,SGMS2,NUDT3B,PLD6,SLC5A9,MMS19 |
| RNA degradation | C1D,CNOT8,PABPC4,EXOSC8,DnaK,ENO1B,CNOT10,EXOSC7,EXOSC10,BTG1 |
| Metabolism of nucleotides | NUDT1,ADSSL1,ADSS,AK8,DCK,TYMP,ITPA,DPYS,ADA,UPP2 |
| Phosphate bond hydrolysis by NUDT proteins | NUDT18,NUDT5,NUDT1,NUDT15 |
Protein Function
NUDT16 has several biochemical functions, for example, GTP binding,ITP binding,XTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NUDT16 itself. We selected most functions NUDT16 had, and list some proteins which have the same functions with NUDT16. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dITP diphosphatase activity | ITPA,DOM3Z,NUDT19 |
| metalloexopeptidase activity | METAP2,METAP2A,DPEP1,DPEP3,NPEPL1,METAP1D,LAP3,METAP1,METAP2B,DPEP2 |
| nucleotide phosphatase activity, acting on free nucleotides | PGP,NTPCR,DUSP11 |
| mRNA binding | ESRP1,RPS3,PCF11,HNRNPAB,XPO5,IGF2BP1,NCBP2,CSTF2,CALR,AGO2 |
| m7G(5)pppN diphosphatase activity | DCPS,DCP2 |
| identical protein binding | VIM,USP2,PLEKHH2,UBE2G2,HAND2,CTSC,TRA@,TRIM55,MICU1,TTR |
| magnesium ion binding | RPS6KA3A,WEE1,FIGNL1,NIM1K,PPM1A,PI4K2A,PRPS2,PDXP,PPM1BA,SERPINB1A |
| snoRNA binding | HEATR1,NHP2,NOP58,NUDT1,UTP6,NOP14,PWP2H,TBL3,PWP2,NUDT7 |
| GTP binding | GIMAP7,MFN2,ARF1L,SUCLG1,ARFRP1,ERCC3,RHOB,DNM1L,EEFSEC,GBP4 |
Interacting Protein
NUDT16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUDT16 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUDT16.
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References
- Song, MG; Bail, S; et al. Multiple Nudix family proteins possess mRNA decapping activity. RNA-A PUBLICATION OF THE RNA SOCIETY 19:390-399(2013).
- Li, Y; Song, MG; et al. Differential utilization of decapping enzymes in mammalian mRNA decay pathways. RNA-A PUBLICATION OF THE RNA SOCIETY 17:419-428(2011).
