NUBPL
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Official Full Name
nucleotide binding protein-like -
Overview
This gene encodes a member of the Mrp/NBP35 ATP-binding proteins family. The encoded protein is required for the assembly of the respiratory chain NADH dehydrogenase (complex I), an oligomeric enzymatic complex located in the inner mitochondrial membrane. The respiratory complex I consists of 45 subunits and 8 iron-sulfur (Fe/S) clusters. This protein is an Fe/S protein that plays a critical role in the assembly of respiratory complex I, likely by transferring Fe/S into the Fe/S-containing complex I subunits. Mutations in this gene cause mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding distinct isoforms have been identified. -
Synonyms
NUBPL;nucleotide binding protein-like;C14orf127, chromosome 14 open reading frame 127;iron-sulfur protein NUBPL;FLJ12660;huInd1;IND1;iron sulfur protein required for NADH dehydrogenase;C14orf127;IND1 homolog;NUBPL_HUMAN;nucleotide binding protein like;Nucleotide-binding protein-like;iron-sulfur protein required for NADH dehydrogenase
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NUBPL-1393H | Recombinant Human NUBPL, GST-tagged | E.coli | Human | GST | 1-289aa | |
| NUBPL-10954M | Recombinant Mouse NUBPL Protein | Mammalian Cell | Mouse | His |
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| NUBPL-574Z | Recombinant Zebrafish NUBPL | Mammalian Cell | Zebrafish | His |
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| NUBPL-3660HCL | Recombinant Human NUBPL 293 Cell Lysate | HEK293 | Human | Non |
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| NUBPL-6243M | Recombinant Mouse NUBPL Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NUBPL-6243M-B | Recombinant Mouse NUBPL Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
NUBPL involved in several pathways and played different roles in them. We selected most pathways NUBPL participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NUBPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
NUBPL has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,ATP binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NUBPL itself. We selected most functions NUBPL had, and list some proteins which have the same functions with NUBPL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CKMT2,PAPOLA,BMPR1BB,STK25,RFK,PAPSS2B,CMPK,ATP1A1A.1,ATP1A4,CHKA |
| 4 iron, 4 sulfur cluster binding | NDUFS8B,MUTYH,DDX11,SDHB,RSAD2,TYW1,NUBP2,REV3L,ACO2,POLD1 |
| metal ion binding | RFNG,RASSF5,HSCB,STK24,SMAD6,GNAI2,PRKCHA,PRDM6,ZDHHC18A,OBSCN |
Interacting Protein
NUBPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUBPL here. Most of them are supplied by our site. Hope this information will be useful for your research of NUBPL.
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References
- Davies, DR; Gelinas, AD; et al. Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109:19971-19976(2012).
- Daikoku, T; Kudoh, A; et al. Postreplicative mismatch repair factors are recruited to Epstein-Barr virus replication compartments. JOURNAL OF BIOLOGICAL CHEMISTRY 281:11422-11430(2006).
