NRG2

  • Official Full Name

    neuregulin 2

  • Overview

    This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described.

  • Synonyms

    NRG2;neuregulin 2;pro-neuregulin-2, membrane-bound isoform;divergent of neuregulin 1;Don 1;HRG2;neural and thymus derived activator for ErbB kinases;NTAK;Pro NRG2;pro-NRG2;OTTHUMP00000159546;OTTHUMP00000198728;OTTHUMP00000224194;OTTHUMP00000224196;OTTHUMP00000230686;divergent of neuregulin-1;neural- and thymus-derived activator for ErbB kinases;DON1

Recombinant Proteins

  • Human
  • Rat
  • Mus musculus
  • Wheat Germ
  • E.coli
  • Mammalian Cell
  • Yeast
  • HEK293
  • In Vitro Cell Free System
  • E.coli expression system
  • Non
  • His
  • His&Fc&Avi
  • His&SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
NRG2-267H Recombinant Human NRG2, GST-tagged Wheat Germ Human Non
NRG2-363H Recombinant Human NRG2 Protein, His-tagged E.coli Human His Phe101~Phe211
NRG2-266H Recombinant Human NRG2 Wheat Germ Human Non
NRG2-2695H Recombinant Human Neuregulin 2 E.coli Human Non
NRG2-4080R Recombinant Rat NRG2 Protein Mammalian Cell Rat His
NRG2-1741H Recombinant Human NRG2 Protein (112-405 aa), His-tagged Yeast Human His 112-405 aa
Nrg2-364R Recombinant Rat Nrg2 Protein, His-tagged E.coli Rat His Leu618~Ser836
NRG2-3739R Recombinant Rat NRG2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
NRG2-3739R-B Recombinant Rat NRG2 Protein Pre-coupled Magnetic Beads HEK293 Rat
NRG2-683H Recombinant Human NRG2 Protein (Cys112-Lys404), His-tagged HEK293 Human His Cys112-Lys404
NRG2-693H Recombinant Human NRG2 Protein (112-405 aa), His-SUMO-tagged E.coli Human His&SUMO 112-405 aa
NRG2-7013HF Recombinant Full Length Human NRG2 Protein In Vitro Cell Free System Human Full L. 850 amino acids
RFL8259RF Recombinant Full Length Rat Pro-Neuregulin-2, Membrane-Bound Isoform(Nrg2) Protein, His-Tagged E.coli expression system Rat His Full L. Full Length of Mature Protein (128-868)
RFL9940MF Recombinant Full Length Mouse Pro-Neuregulin-2, Membrane-Bound Isoform(Nrg2) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length of Mature Protein (20-756)

    Involved Pathway

    NRG2 involved in several pathways and played different roles in them. We selected most pathways NRG2 participated on our site, such as ErbB signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NRG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway PAK6,KRAS,AREG,PAK6B,RPS6KB1,RAF1B,CBLC,EGFRA,PIK3CG,PIK3R1

    Protein Function

    NRG2 has several biochemical functions, for example, growth factor activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NRG2 itself. We selected most functions NRG2 had, and list some proteins which have the same functions with NRG2. You can find most of the proteins on our site.

    Function Related Protein
    receptor binding TMED1,LHB,FASLG,TGFB2,AMN,PTK2BB,DIAPH1,ALCAM,AGXT,F2
    growth factor activity FGF16,CSPG5,GDF9,HBEGF,BMP7,BMP2,IL7,EFEMP1,BMP7A,HGF

    Interacting Protein

    NRG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NRG2.

    Resources

    Gene Families

    Growth Factors

    Research Area

    Diabetic Peripheral Neuropathy
    Neuronal Lineage Markers
    Epidermal Growth Factor (EGF)
    EGF Ligands

    References

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All NRG2 Products

    Required fields are marked with *

    My Review for All NRG2 Products

    Required fields are marked with *