NRCAM
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Official Full Name
neuronal cell adhesion molecule -
Overview
Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene. Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
NRCAM;KIAA0343;MGC138845;MGC138846
Recombinant Proteins
- Human
- Chicken
- HEK293
- Wheat Germ
- Mammalian Cell
- E.coli
- Mammalian cells
- Fc
- Non
- His
- His&GST
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NRCAM-180H | Recombinant Human NRCAM Protein, Fc-tagged | HEK293 | Human | Fc |
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| NRCAM-30412TH | Recombinant Human NRCAM | Wheat Germ | Human | Non | 110 amino acids |
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| NRCAM-544H | Recombinant Human NRCAM | Mammalian Cell | Human | His |
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| NRCAM-6818C | Recombinant Chicken NRCAM | Mammalian Cell | Chicken | His |
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| NRCAM-1220HCL | Recombinant Human NRCAM cell lysate | Human | Non |
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| NRCAM-1665H | Recombinant Human NRCAM protein, His & GST-tagged | E.coli | Human | His&GST | Gln25~Arg143 |
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| NRCAM-3677H | Recombinant Human NRCAM Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| NRCAM-3677H-B | Recombinant Human NRCAM Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| NRCAM-4737H | Recombinant Human NRCAM Protein (Gln25-Asn600), C-Fc tagged | Mammalian cells | Human | Fc | Gln25-Asn600 |
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| NRCAM-583H | Recombinant Human NRCAM protein, His-tagged | HEK293 | Human | His | Gln25-Gln1167 |
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| NRCAM-6113H | Recombinant Human NRCAM Protein, GST-tagged | Wheat Germ | Human | GST |
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| NRCAM-8675H | Recombinant Human NRCAM protein, hFc-tagged | HEK293 | Human | Fc | Gln25-Gln1167 |
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Involved Pathway
NRCAM involved in several pathways and played different roles in them. We selected most pathways NRCAM participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with NRCAM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | CLDN18,HLA-DQA2,HLA-DMA,ICAM2,LRRC4B,GLG1,PVRL3,HLA-DRA,MHC2DEB,CADM1 |
Protein Function
NRCAM has several biochemical functions, for example, ankyrin binding,protein binding,protein binding involved in heterotypic cell-cell adhesion. Some of the functions are cooperated with other proteins, some of the functions could acted by NRCAM itself. We selected most functions NRCAM had, and list some proteins which have the same functions with NRCAM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding involved in heterotypic cell-cell adhesion | NFASC,GLDN |
| ankyrin binding | SLC4A1,RHBG,KCTD6,FLNC,SCN5A,CDH1,OBSCN,RHCG,ATP1A1,PTBP3 |
| protein binding | CD160,SH3PXD2A,SH2B2,MTX2,ZNF394,CDKN2D,MRPS23,ARAP1,JMY,C1orf187 |
Interacting Protein
NRCAM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRCAM here. Most of them are supplied by our site. Hope this information will be useful for your research of NRCAM.
HSPA12A;valS;MAGI3;MACF1;FRMD5
Resources
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References
- Devaux, JJ; Odaka, M; et al. Nodal proteins are target antigens in Guillain-Barre syndrome. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 17:62-71(2012).
- Pollard, JD; Armati, PJ; et al. CIDP - the relevance of recent advances in Schwann cell/axonal neurobiology. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 16:15-23(2011).
