NR6A1

  • Official Full Name

    nuclear receptor subfamily 6, group A, member 1

  • Overview

    This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]

  • Synonyms

    NR6A1;nuclear receptor subfamily 6, group A, member 1;RTR;GCNF;NR61;hRTR;CT150;GCNF1;hGCNF;nuclear receptor subfamily 6 group A member 1;germ cell nuclear factor variant 1;retinoid receptor-related testis-specific receptor;retinoic acid receptor-related testis-associated receptor

Recombinant Proteins

  • Mouse
  • Human
  • Mammalian Cells
  • Wheat Germ
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • His
  • Non
  • His&T7
  • GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
NR6A1-10876M Recombinant Mouse NR6A1 Protein Mammalian Cells Mouse His
NR6A1-26466TH Recombinant Human NR6A1 Wheat Germ Human Non 475 amino acids
NR6A1-7840H Recombinant Human NR6A1 protein, His & T7-tagged E.coli Human His&T7 Glu282~Glu480
NR6A1-3704HCL Recombinant Human NR6A1 293 Cell Lysate HEK293 Human Non
NR6A1-349HF Recombinant Full Length Human NR6A1 Protein In Vitro Cell Free System Human Full L. 475 amino acids
NR6A1-6102H Recombinant Human NR6A1 Protein, GST-tagged Wheat Germ Human GST
NR6A1-6192M Recombinant Mouse NR6A1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
NR6A1-6192M-B Recombinant Mouse NR6A1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
NR6A1-6748HF Recombinant Full Length Human NR6A1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 475 amino acids

    Involved Pathway

    NR6A1 involved in several pathways and played different roles in them. We selected most pathways NR6A1 participated on our site, such as Developmental Biology,Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR6A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Nuclear Receptor transcription pathway NR1I3,NR1D2A,NRBF2B,NR2C2,NRBP1,RORAA,NR5A1A,PPARAA,NR1D2,NR1H3
    Generic Transcription Pathway ZNF480,NRBF2,ZNF263,ZNF565,MED8,ZNF398,ZNF548,ZNF689,RORAA,ZNF839
    Gene Expression ZNF394,POLR3GLA,ZNF227,TSNAX,MYBL1,PCBP2,ZNF554,WHSC2,SNAPC5,PAPOLA
    Developmental Biology CNKSR1,BNIP2,HFE2,SPRED2,RND1L,TRPC7,SALL4,FGF18B,MED22,POU5F3
    POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation FOXD3,TDGF1
    Transcriptional regulation of pluripotent stem cells SALL4,LIN28A,NR5A1,TDGF1,POU5F3,HIF3A,PRDM14,FOXD3

    Protein Function

    NR6A1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR6A1 itself. We selected most functions NR6A1 had, and list some proteins which have the same functions with NR6A1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding BATF2,PITX1,BCL11B,JUN,ATF3,ZNF680,POU3F2,ZNF114,NDN,GCFC2
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding NOBOX,NKX2-8,NFKB2,NR2E1,HEYL,NKX2,ZFP292,ELK1,CREB3L1,CRX
    steroid hormone receptor activity PPARA,ESR2B,VDR,RXRAA,RXRAB,NR6A1B,NR2F6A,RORAB,NR2F2,NR1D2A
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding NR1I2,ESRRA,NR2F6B,NR0B1,HNF4G,NR2F6,NR2F2,PPARDB,NR1D2,Ar
    DNA binding SOX21B,RYBP,TLR8,HIST1H2AE,HIST2H3C,PAX3A,KIN,GON4L,DMRT2,TFDP1A
    protein homodimerization activity SLC22A6,ANXA9,ODZ4,HMGCR,TLR13,NTSR1,SP1,UGT1A7,FGFR1OP2,GLA
    sequence-specific DNA binding TEFA,NLRP3,PPARGC1A,EOMES,TA,HOXD10,FOXQ1A,FOXQ2,HOXC4,JUNBA
    zinc ion binding RNF145B,ZDHHC20,NR2C1,ZNF331,RXRBA,ZFYVE20,MYNN,THRAA,TRIM105,ING5

    Interacting Protein

    NR6A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR6A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR6A1.

    GNB5

    Resources

    Research Area

    Germ Cell Markers
    Embryonic and Induced Pluripotent Stem Cell Markers
    Neural Stem Cell Markers

    References

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