NPHP4
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Official Full Name
nephronophthisis 4 -
Overview
This gene encodes a protein involved in renal tubular development and function. This protein interacts with nephrocystin, and belongs to a multifunctional complex that is localized to actin- and microtubule-based structures. Mutations in this gene are associated with nephronophthisis type 4, a renal disease, and with Senior-Loken syndrome type 4, a combination of nephronophthisis and retinitis pigmentosa. -
Synonyms
NPHP4;nephronophthisis 4;nephrocystin-4;KIAA0673;nephrocystin 4;nephroretinin;POC10;POC10 centriolar protein homolog (Chlamydomonas);SLSN4;NPHP4_HUMAN;POC10 centriolar protein homolog
Recombinant Proteins
- Mouse
- Human
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NPHP4-10821M | Recombinant Mouse NPHP4 Protein | Mammalian Cell | Mouse | His |
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| NPHP4-6029H | Recombinant Human NPHP4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| NPHP4-6159M | Recombinant Mouse NPHP4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NPHP4-6159M-B | Recombinant Mouse NPHP4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| NPHP4-6622HF | Recombinant Full Length Human NPHP4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 81 amino acids |
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| Nphp4-6758M | Recombinant Mouse Nphp4 Protein (Met1-Gly478), C-His tagged | E.coli | Mouse | His | Met1-Gly478 |
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| Nphp4-6759M | Recombinant Mouse Nphp4 Protein (Gly760-Gln1425), C-His tagged | E.coli | Mouse | His | Gly760-Gln1425 |
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Involved Pathway
NPHP4 involved in several pathways and played different roles in them. We selected most pathways NPHP4 participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPHP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Organelle biogenesis and maintenance | MRPL52,IFT-20,RPGRIP1L,MRPS28,LZTFL1,TTC8,PPRC1,PKD2,TNPO1,WDR35 |
| Anchoring of the basal body to the plasma membrane | RPGRIP1L,TCTN3,IQCB1,TMEM67,DCTN2,ACTR1A,HAUS2,B9D1,TUBB4B,CCDC41 |
| Assembly of the primary cilium | DYNC1H1,TCTN1,CLUAP1,MAPRE1B,ARL13B,CC2D2A,RAB3IP,SDCCAG8,CNGA5,CCDC41 |
| Signal Transduction | ARHGEF3,TAC2,PROK2,OR52B4,WWOX,OR4D2,RHOT1A,GPR55A,RHOUA,PLEKHG2 |
| Signaling by Hippo | AMOTL2A,AMOTL2,MOB1BA,AMOTL2B,TJP2B |
Protein Function
NPHP4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPHP4 itself. We selected most functions NPHP4 had, and list some proteins which have the same functions with NPHP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ADCK3,SCFD1,GIPC2,GABRG2,VAMP5,ZBTB7C,SPACA3,HNRNPUL1,OLFM4,EXOSC4 |
Interacting Protein
NPHP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPHP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NPHP4.
Nphp1;Rpgrip1l;Iqcb1;Nphp1;a2bfa6_mouse;Calu
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