NPC2
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Official Full Name
Niemann-Pick disease, type C2 -
Overview
This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy. [provided by RefSeq, Jul 2008] -
Synonyms
NPC2;Niemann-Pick disease, type C2;HE1;EDDM1;epididymal secretory protein E1;epididymal protein 1;tissue-specific secretory protein;human epididymis-specific protein 1;Niemann-Pick disease type C2 protein
Recombinant Proteins
- Mouse
- Human
- Chicken
- Rhesus macaque
- Rat
- Zebrafish
- Dog
- Mammalian Cell
- HEK293
- Human Cell
- E.coli
- Yeast
- Mammalian cells
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&GST
- His&Fc&Avi
- His&SUMO
- GST
Involved Pathway
NPC2 involved in several pathways and played different roles in them. We selected most pathways NPC2 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | CTSH,ATP6V0A1B,LAPTM5,AP4M1,GNSA,IDS,ATP6V0A2B,TCEAL4,MAN2B1,LGMN |
Protein Function
NPC2 has several biochemical functions, for example, cholesterol binding,enzyme binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPC2 itself. We selected most functions NPC2 had, and list some proteins which have the same functions with NPC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DPYSL3,BCL2L10,NCBP1,ALDH1A2,PEBP1,GDF7,QRICH1,NXF1,FBP1,SCARA5 |
| enzyme binding | GSTM7,POLB,PTPLA,Alb,ZFP36,PYCARD,TSPAN15,VAPB,TUT1,C6orf211 |
| cholesterol binding | OSBP2,APOA5,APOA1A,APOF,TSPO,CAV1,ERLIN1,STARD6,NPC1,OSBPL2 |
Interacting Protein
NPC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NPC2.
cholesterol;q81tt5_bacan
Resources
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References
- Kwiatkowska, K; Marszalek-Sadowska, E; et al. Visualization of cholesterol deposits in lysosomes of Niemann-Pick type C fibroblasts using recombinant perfringolysin O. ORPHANET JOURNAL OF RARE DISEASES 9:-(2014).
- Liao, YJ; Lin, MW; et al. Characterization of Niemann-Pick Type C2 Protein Expression in Multiple Cancers Using a Novel NPC2 Monoclonal Antibody. PLOS ONE 8:-(2013).
