NOL3
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Official Full Name
nucleolar protein 3 (apoptosis repressor with CARD domain) -
Overview
This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] -
Synonyms
NOL3;nucleolar protein 3 (apoptosis repressor with CARD domain);ARC;FCM;MYP;NOP;NOP30;nucleolar protein 3;nucleolar protein of 30 kDa;muscle-enriched cytoplasmic protein
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- HEK293
- Mammalian Cell
- HEK293T
- E. coli
- Mamanlian cells
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Myc&DDK
- Non
- His&SUMO
- His&Fc&Avi
- Flag
Involved Pathway
NOL3 involved in several pathways and played different roles in them. We selected most pathways NOL3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NOL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
NOL3 has several biochemical functions, for example, RNA binding,calcium ion binding,caspase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NOL3 itself. We selected most functions NOL3 had, and list some proteins which have the same functions with NOL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | EIF5A,ADARB1A,SYNJ2,EIF3B,PSMA1,HNRNPD,RBM48,DAZL,CPSF5,CPEB3 |
| calcium ion binding | CALB2A,CDH10,EPDR1,ENPP1,SLC25A25B,ANXA1B,PCDH2G3,PCDH2AA3,ACTN4,SPTA1 |
| protein binding | SWAP70,APBB1,RAB7,FLCN,EPHA3,CDCA5,HSPBP1,PLAU,WDR6,SOX5 |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | VIL1,SNCA,DPEP1,IGF1RA,PRDX5,PRDX3,BIRC8,RPS6KA3,AVP,ARRB1 |
| identical protein binding | BIRC5,GOT2A,NFKBIA,CCL4,DPP9,APAF1,SERPINA1E,CAD,MTSS1,UBE2G2 |
| death effector domain binding | CFLARA,CFLAR,FADD,CASP8L1,CASP8,CASP10 |
| caspase binding | BFAR,FADD,MAGEA3 |
| death receptor binding | PRDM4,CFLAR,TNFSF15,BID,RIPK1,FASLG,FEM1B,CASP8,Fasl,TMBIM1 |
Interacting Protein
NOL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOL3.
CASP8;TINF2;PNKP;PACSIN3;VASP;TERF1;SIRPA;NIF3L1;POT1;ETNK2;TERF2IP
Resources
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References
- Mak, PY; Mak, DH; et al. Apoptosis repressor with caspase recruitment domain modulates second mitochondrial-derived activator of caspases mimetic-induced cell death through BIRC2/MAP3K14 signalling in acute myeloid leukaemia. BRITISH JOURNAL OF HAEMATOLOGY 167:376-384(2014).
- Macerollo, A; Mencacci, NE; et al. Screening of mutations in NOL3 in a myoclonic syndromes series. JOURNAL OF NEUROLOGY 261:1830-1831(2014).
