NOD2
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Official Full Name
nucleotide-binding oligomerization domain containing 2 -
Overview
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. -
Synonyms
NOD2;nucleotide-binding oligomerization domain containing 2;CD;ACUG;BLAU;IBD1;NLRC2;NOD2B;CARD15;CLR16.3;PSORAS1;nucleotide-binding oligomerization domain-containing protein 2;OTTHUMP00000164224;OTTHUMP00000236088;NOD-like receptor C2;NLR family, CARD domain containing 2;inflammatory bowel disease protein 1;caspase recruitment domain protein 15;nucleotide-binding oligomerization domain 2;caspase recruitment domain family, member 15;caspase recruitment domain-containing protein 15;nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NOD2-1369B | Recombinant Bovine NOD2 protein, His-KSI-tagged | E.coli | Bovine | His&KSI | 1-191aa |
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Involved Pathway
NOD2 involved in several pathways and played different roles in them. We selected most pathways NOD2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NOD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
NOD2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by NOD2 itself. We selected most functions NOD2 had, and list some proteins which have the same functions with NOD2. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
NOD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOD2.
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References
- Ammerdorffer, A; Schoffelen, T; et al. Recognition of Coxiella burnetii by Toll-like Receptors and Nucleotide-Binding Oligomerization Domain-like Receptors. JOURNAL OF INFECTIOUS DISEASES 211:978-987(2015).
- Xie, JS; Belosevic, M; et al. Functional characterization of receptor-interacting serine/threonine kinase 2 (RIP2) of the goldfish (Carassius auratus L.). DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:76-85(2015).
