NLRP2
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Official Full Name
NLR family, pyrin domain containing 2 -
Overview
NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in;the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be;involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 (PubMed;12563287)). -
Synonyms
NLRP2;NLR family, pyrin domain containing 2;NACHT, leucine rich repeat and PYD containing 2 , NALP2;NACHT, LRR and PYD domains-containing protein 2;CLR19.9;FLJ20510;NBS1;nucleotide binding oligomerization domain;leucine rich repeat and pyrin domai
Recombinant Proteins
- Human
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NLRP2-3681H | Recombinant Human NLRP2 protein, His-tagged | E.coli | Human | His | 1-350 aa | |
| NLRP2-3046R | Recombinant Rhesus monkey NLRP2 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| NLRP2-3800HCL | Recombinant Human NLRP2 293 Cell Lysate | HEK293 | Human | Non |
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| NLRP2-179H | Recombinant Human NLRP2 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| NLRP2-2865R | Recombinant Rhesus Macaque NLRP2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| NLRP2-2865R-B | Recombinant Rhesus Macaque NLRP2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| NLRP2-36H | Recombinant Human NLRP2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| NLRP2-5921H | Recombinant Human NLRP2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| NLRP2-6755HF | Recombinant Full Length Human NLRP2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 846 amino acids |
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Involved Pathway
NLRP2 involved in several pathways and played different roles in them. We selected most pathways NLRP2 participated on our site, such as NOD pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NOD pathway | PRDM1,AAMP,COPS6,NLRP3,NLRP10,NLRP4,NLRP12,SUGT1,NLRP7 |
Protein Function
NLRP2 has several biochemical functions, for example, ATP binding,Pyrin domain binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLRP2 itself. We selected most functions NLRP2 had, and list some proteins which have the same functions with NLRP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Pyrin domain binding | PYCARD,CASPA |
| ATP binding | PIP4K2A,MCM3L,GK5,ATP13A5,DDX51,PDGFRA,ADRBK2,SRPK3,CDC42BPB,PRKY |
| protein binding | PAK3,SLC30A1,PSMD4,SBNO2,ITPR1,MIIP,JAM3B,RBM15B,OBFC2B,TRIM59 |
Interacting Protein
NLRP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLRP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NLRP2.
PYDC2;H2AFX;WRN;RBBP6;BECN1;TPP1;NLRP5;TTF1;TAF13;BCL7B;CRIPT
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