NLRP12
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Official Full Name
NLR family, pyrin domain containing 12 -
Overview
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Alternatively spliced transcript variants encoding distinct isoforms have been described but the full-length nature of some of these has not been determined. -
Synonyms
NLRP12;NLR family, pyrin domain containing 12;NACHT, leucine rich repeat and PYD containing 12 , NALP12;NACHT, LRR and PYD domains-containing protein 12;CLR19.3;Monarch1;nucleotide binding oligomerization domain;leucine rich repeat and pyrin domain
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NLRP12-10717M | Recombinant Mouse NLRP12 Protein | Mammalian Cell | Mouse | His |
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| NLRP12-3801HCL | Recombinant Human NLRP12 293 Cell Lysate | HEK293 | Human | Non |
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| NLRP12-6095M | Recombinant Mouse NLRP12 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NLRP12-6095M-B | Recombinant Mouse NLRP12 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
NLRP12 involved in several pathways and played different roles in them. We selected most pathways NLRP12 participated on our site, such as NOD pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRP12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NOD pathway | NLRP3,PRDM1,AAMP,COPS6,NLRP7,NLRP10,SUGT1,NLRP4,NLRP2 |
Protein Function
NLRP12 has several biochemical functions, for example, ATP binding,cysteine-type endopeptidase activator activity involved in apoptotic process,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLRP12 itself. We selected most functions NLRP12 had, and list some proteins which have the same functions with NLRP12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase activator activity involved in apoptotic process | CTSH,CARD8,GNB2L1,RPS27L,NOD1,CTSC,CASP1,BAD,BCL2L13,NLRP1 |
| ATP binding | DDX18,NAIP7,AGAP2,PRKX,HSP90B1,MAP3K4,PKN3,PEX1,IFIH1,DHX29 |
| protein binding | PNKP,FGR,XPA,TEX10,ZNF567,UTP14A,ALPL,EDDM3B,C1GALT1C1,GPR77 |
Interacting Protein
NLRP12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLRP12 here. Most of them are supplied by our site. Hope this information will be useful for your research of NLRP12.
Dlg4;a8k1f4_human;b4dyc6_human;SGTA;HSP90AA1;STIP1;MLF1;HSF2;PSMD2;FKBP5;CDC37;Usp19;q53fc7_human;HSP90AB1;NUDCD3;Hacd3;q96be0_human;TTC1;PPP5C;AARSD1
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