NLRP11
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Official Full Name
NLR family, pyrin domain containing 11 -
Overview
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs,;such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a;NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636),;also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD).;NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in;multiprotein complexes called inflammasomes (Tschopp et al., 2003 (PubMed 12563287)). -
Synonyms
NLRP11;NLR family, pyrin domain containing 11;NACHT, leucine rich repeat and PYD containing 11 , NALP11;NACHT, LRR and PYD domains-containing protein 11;CLR19.6;NOD17;nucleotide binding oligomerization domain;leucine rich repeat and pyrin domain containing 11;PAN10;PYPAF6;FLJ26273;NACHT leucine rich repeat and PYD containing 11;NACHT LRR and PYD domains containing protein 11;NAL11_HUMAN;NALP11;NLR family pyrin domain containing 11;Nucleotide binding oligomerization domain protein 17;Nucleotide-binding oligomerization domain protein 17;Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 11;PAAD and NACHT containing protein 10B;PAAD and NACHT domain containing protein 10;PAAD-and NACHT domain-containing protein 10;PYPAF7;PYRIN containing APAF1 like protein 6;PYRIN-containing APAF1-like protein 6;PAAD- and NACHT-containing protein 10;PAAD- and NACHT-containing protein 10B;NACHT, LRR and PYD containing protein 11;NACHT, leucine rich repeat and PYD containing 11
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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| NLRP11-3045R | Recombinant Rhesus monkey NLRP11 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| NLRP11-3802HCL | Recombinant Human NLRP11 293 Cell Lysate | HEK293 | Human | Non |
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| NLRP11-2864R | Recombinant Rhesus Macaque NLRP11 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| NLRP11-2864R-B | Recombinant Rhesus Macaque NLRP11 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| NLRP11-5919H | Recombinant Human NLRP11 Protein, GST-tagged | Wheat Germ | Human | GST |
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| NLRP11-6752HF | Recombinant Full Length Human NLRP11 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 1033 amino acids |
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Involved Pathway
NLRP11 involved in several pathways and played different roles in them. We selected most pathways NLRP11 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRP11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
NLRP11 has several biochemical functions, for example, ATP binding,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLRP11 itself. We selected most functions NLRP11 had, and list some proteins which have the same functions with NLRP11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | HNRNPA1,ZNF622,TRIM56,RPLP0,TRAP1,RPN1,EDF1,RPL18A,FAM46A,HLA-A |
| ATP binding | DYNC1H1,NPR2,ARAF,PSMC1A,KIF22,CDC42BPA,MAP2K1,P2RX4B,ALK,PRKCH |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen | MOXD1L,MOXD2,MOXD1 |
Interacting Protein
NLRP11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLRP11 here. Most of them are supplied by our site. Hope this information will be useful for your research of NLRP11.
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References
- Beardsley, AJ; Li, Y; et al. Characterization of a diverse secretome generated by the mouse preimplantation embryo in vitro. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 8:-(2010).
- Akhter, A; Caution, K; et al. Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization. IMMUNITY 37:35-47(2012).
