NKX6-1
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Official Full Name
NK6 homeobox 1 -
Overview
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription;regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) (PubMed;15056733).
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His&GST
- His
- N-GST,C-His
- His&Fc&Avi
- GST
Involved Pathway
NKX6-1 involved in several pathways and played different roles in them. We selected most pathways NKX6-1 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX6-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Maturity onset diabetes of the young | SLC2A2,ONECUT1,HNF1B,NEUROD1,INS1,PDX1,MNX1,IAPP,HNF1A,BHLHA15 |
Protein Function
NKX6-1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX6-1 itself. We selected most functions NKX6-1 had, and list some proteins which have the same functions with NKX6-1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | POU2F1A,HOXA13A,HOXC13,CXXC5,NKX2,HOXD1,POU1F1,NR1D2A,MSXD,HOXB6B |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | KCNIP3,CREBBP,MZF1,ZKSCAN3,RELA,TFAP2A,NFE2L3,ATF7,CUX2,MYPOP |
| transcription factor activity, sequence-specific DNA binding | SCML1,BATF3,ZNF182,GRHL3,HOXA3,CREB3,POU2F1B,POU2F1A,ZNF165,SOX7 |
| chromatin binding | SHMT2,HOXD10,GLI2,PRDM11,HMGB3A,ARX,NIPBL,MTA1,C19orf40,PRKCBB |
| DNA binding | TTF2,CHRAC1,MYO18A,XRN1,TAF9,CRSP7,RORAB,ADNPA,RFX1A,GFI1B |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | FOXD1,RBPJL,GMEB1,IRF4,MLXIPL,MEOX1,CLOCK,HHEX,ATF4,SPI1 |
Interacting Protein
NKX6-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX6-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX6-1.
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References
- Hald, J; Galbo, T; et al. Pancreatic islet and progenitor cell surface markers with cell sorting potential. DIABETOLOGIA 55:154-165(2012).
- Conrad, R; Jablonka, S; et al. Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2011).
