NIPBL
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Official Full Name
NIPBL Nipped-B homolog (Drosophila) -
Overview
Background:The 26 S proteasome is a protein complex with a molecular mass of 2000 kDa. It is essential not only for eliminating damaged or misfolded proteins but also for degrading short lived regulatory proteins involved in cell cycle regulation DNA repair signal transduction apoptosis and metabolic regulation.Rpn3p is essential non-ATPase regulatory subunit of the 26S proteasome lid similar to the p58 subunit of the human 26S proteasome. -
Synonyms
NIPBL;Nipped-B homolog (Drosophila);nipped-B-like protein;DKFZp434L1319;FLJ11203;FLJ12597;FLJ13354;FLJ13648;IDN3;Scc2;sister chromatid cohesion 2 homolog (yeast);delangin;SCC2 homolog;sister chromatid cohesion 2 homolog;CDLS;CDLS1;IDN3-B;FLJ44854
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NIPBL-1296H | Recombinant Human NIPBL, GST-tagged | E.coli | Human | GST | 2523-2686aa | |
| NIPBL-10676M | Recombinant Mouse NIPBL Protein | Mammalian Cell | Mouse | His |
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| NIPBL-5872H | Recombinant Human NIPBL Protein, GST-tagged | Wheat Germ | Human | GST |
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| NIPBL-6073M | Recombinant Mouse NIPBL Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NIPBL-6073M-B | Recombinant Mouse NIPBL Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| NIPBL-6635HF | Recombinant Full Length Human NIPBL Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 175 amino acids |
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Involved Pathway
NIPBL involved in several pathways and played different roles in them. We selected most pathways NIPBL participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Cohesin Loading onto Chromatin, which may be useful for your reference. Also, other proteins which involved in the same pathway with NIPBL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitotic Telophase/Cytokinesis | NIPBLB,NIPBLA,MAU2,NUDC |
| Cell cycle | PDS5A,RAD9A,POLD3,YWHABB,CDK4,TUBG2,YWHAE2,MLF1IP,HDAC6,ORC6L |
| Cell Cycle, Mitotic | DULLARD,SGOL1,CEP78,MYBL2,MCM8,HIST2H3C,CDK11A,CLASP1A,ZWILCH,NUDC |
| Cohesin Loading onto Chromatin | NIPBLA,WAPAL,NIPBLB,STAG1,STAG2,PDS5B,MAU2,PDS5A |
| M Phase | CENPC1,SGOL1,ANKLE2,NUDC,STAG1,CCDC99,NEK6,STAG2,BLZF1,LEMD3 |
Protein Function
NIPBL has several biochemical functions, for example, chromatin binding,chromo shadow domain binding,histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NIPBL itself. We selected most functions NIPBL had, and list some proteins which have the same functions with NIPBL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mediator complex binding | MED1,SMC3,SMC1A |
| chromo shadow domain binding | CHAF1A,TRIM28,LBR,ATRX,SP100 |
| protein binding | NPHP1,C16orf70,ZNF643,RCBTB2,BMP1,CIB4,CEP120,TWF2,SULT4A1,MSN |
| histone deacetylase binding | KLF4,NCOR2,HIF1A,RAD9A,NCOR1,MAGEA2B,CBX5,NKX3,SP1,XBP1 |
| protein C-terminus binding | BCL10,SCLT1,SIRT1,ARL6IP5,CITED1,MAPRE1,VAMP2,RABAC1,XRCC5,OPRL1 |
| chromatin binding | NFATC3,C19orf40,MITF,RDBP,EZH1,CREBBP,DNMT3B,POU4F2,HMGB3,PRDM11 |
| protein N-terminus binding | KCNIP1,ID1,PIAS3,RPS21,ATM,FEZ1,KCNQ2,STXBP1,SYNGR3,RPA2 |
Interacting Protein
NIPBL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NIPBL here. Most of them are supplied by our site. Hope this information will be useful for your research of NIPBL.
CBX5;CDK6;PRSS23;DBN1;fusA;pepP;adP1;RPL10;Cbx1;SNW1;Rpl35;LDHD;TFG;CDC5L;SUCO;MAU2
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