NFKBIZ
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Official Full Name
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -
Overview
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion;of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family;of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B;proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I;kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been;found for this gene. -
Synonyms
NFKBIZ;nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta;NF-kappa-B inhibitor zeta;FLJ34463;MAIL;ikB-zeta;ikappaBzeta;IkappaB-zeta;I-kappa-B-zeta;Ikappa B-zeta variant 3;IL-1 inducible nuclear ankyrin-repeat prot
Recombinant Proteins
- Mouse
- Chicken
- Human
- Mammalian Cell
- HEK293
- E.coli
- His
- Non
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NFKBIZ-10629M | Recombinant Mouse NFKBIZ Protein | Mammalian Cell | Mouse | His |
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| NFKBIZ-1401C | Recombinant Chicken NFKBIZ | Mammalian Cell | Chicken | His |
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| NFKBIZ-3845HCL | Recombinant Human NFKBIZ 293 Cell Lysate | HEK293 | Human | Non |
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| NFKBIZ-451H | Recombinant Human NFKBIZ Protein, His-tagged | E.coli | Human | His | Val422~Thr651 |
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| Nfkbiz-452M | Recombinant Mouse Nfkbiz Protein, His-tagged | E.coli | Mouse | His | Met414~Ala654 |
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| NFKBIZ-458H | Recombinant Human NFKBIZ protein, GST-tagged | E.coli | Human | GST | 369-718 aa |
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| NFKBIZ-6043M | Recombinant Mouse NFKBIZ Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NFKBIZ-6043M-B | Recombinant Mouse NFKBIZ Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
NFKBIZ involved in several pathways and played different roles in them. We selected most pathways NFKBIZ participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFKBIZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | Itgam&Itgb2,CCNT1,DEFA3,PER2,ETV4,FLT1,HIST2H3C2,NUPR1,TRAF1,IGFBP3 |
Protein Function
NFKBIZ has several biochemical functions, for example, protein binding,transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NFKBIZ itself. We selected most functions NFKBIZ had, and list some proteins which have the same functions with NFKBIZ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription cofactor activity | ZFP667,AIRE,TFB2M,ZNF763,KAT2B,FAM48A,NSD1,LDB2,ZFP865,ZMYND11 |
| protein binding | DCX,ARSA,BCL2A1,SYT6,TELO2,ULK1,ATG101,ELANE,USP46,RPL12 |
Interacting Protein
NFKBIZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFKBIZ here. Most of them are supplied by our site. Hope this information will be useful for your research of NFKBIZ.
Akirin2;NFKB1;STAT3;Smarcd1
Resources
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References
- Disanto, G; Sandve, GK; et al. DNase hypersensitive sites and association with multiple sclerosis. HUMAN MOLECULAR GENETICS 23:942-948(2014).
- Nozawa, K; Fujishiro, M; et al. Inhibition of Connective Tissue Growth Factor Ameliorates Disease in a Murine Model of Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM 65:1477-1486(2013).
- Perotti, C; Wiedl, T; et al. Characterization of mammary epithelial cell line HC11 using the NIA 15k gene array reveals potential regulators of the undifferentiated and differentiated phenotypes. DIFFERENTIATION 78:269-282(2009).
