NFAT5
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Official Full Name
nuclear factor of activated T-cells 5, tonicity-responsive -
Overview
The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NFAT5;nuclear factor of activated T-cells 5, tonicity-responsive;nuclear factor of activated T-cells 5;KIAA0827;NF AT5;NFATL1;NFATZ;OREBP;TONEBP;NFAT-like protein 1;TonE-binding protein;glutamine rich protein H65;T-cell transcription factor NF
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NFAT5-1187HCL | Recombinant Human NFAT5 cell lysate | HEK293T | Human | Myc&DDK |
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| NFAT5-30376TH | Recombinant Human NFAT5 | Wheat Germ | Human | Non | 110 amino acids |
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| NFAT5-3969R | Recombinant Rat NFAT5 Protein | Mammalian Cell | Rat | His |
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| NFAT5-4235C | Recombinant Chicken NFAT5 | Mammalian Cell | Chicken | His |
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| NFAT5-3628R | Recombinant Rat NFAT5 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| NFAT5-3628R-B | Recombinant Rat NFAT5 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
NFAT5 involved in several pathways and played different roles in them. We selected most pathways NFAT5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NFAT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
NFAT5 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFAT5 itself. We selected most functions NFAT5 had, and list some proteins which have the same functions with NFAT5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | SKIL,NR1H2,FOXJ1,SNAI3,MAX,SOX1,ELK1,DDN,PITX1,CC2D1A |
| transcription factor activity, sequence-specific DNA binding | RARAA,ZIC2,RHOXF1,CDX2,PAX8,CSRNP3,HIRA,BUD31,HNF1BA,POU5F1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | TP53,ETV6,NFKB2,JUN,ZIC3,NOBOX,YBX1,JUNB,FOXL2,ELK3 |
| protein binding | IRAK2,STAP2,CCDC93,JUN,MOAP1,KRT25,ZNF177,PKD2,TCF7L2,DEDD2 |
Interacting Protein
NFAT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFAT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFAT5.
DDX5;DDX17;TBC1D4;mtfA;dsdna_dadt:dadt;lcn2_human_gene;s100a4_human_gene;ORF
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References
- Wiig, H; Schroder, A; et al. Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. JOURNAL OF CLINICAL INVESTIGATION 123:2803-2815(2013).
- Shaterian, A; Borboa, A; et al. Non-invasive detection of spatio-temporal activation of SBE and NFAT5 promoters in transgenic reporter mice following stroke. NEUROPATHOLOGY 32:118-123(2012).
