NEU3

  • Official Full Name

    sialidase 3 (membrane sialidase)

  • Overview

    This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]

  • Synonyms

    NEU3;sialidase 3 (membrane sialidase);SIAL3;sialidase-3;neuraminidase 3;membrane sialidase;ganglioside sialidase;N-acetyl-alpha-neuraminidase 3

Recombinant Proteins

  • Rat
  • Human
  • Mouse
  • Mammalian Cell
  • HEK293
  • E.coli
  • Mammalian cells
  • HEK293T
  • His
  • His&Fc&Avi
  • GST
  • Flag
  • Myc&DDK

    Involved Pathway

    NEU3 involved in several pathways and played different roles in them. We selected most pathways NEU3 participated on our site, such as Asparagine N-linked glycosylation,Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein,Glycosphingolipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEU3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Asparagine N-linked glycosylation GORASP1,USO1,NEU4,TRAPPC4,TRAPPC6A,MGAT4B,ST6GAL2B,ST8SIA2,TRAPPC6BL,SEC22C
    Other glycan degradation HEXDC,MANBA,NEU1,FUCA1.1,FUCA1,GBA,HEXA,HEXB,MAN2B1,MAN2B2
    Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein DPAGT1,NANP,ST3GAL3A,ST6GAL2B,MPDU1,ZNF408,ST6GALNAC1.2,SLC35A1,ST8SIA2,ST8SIA3
    Metabolism UGT1B4,SULT2ST1,Sult2a2,YAP1,GCHFR,CTGF,ADAL,CLPS,OAZ3,CYP2AD2
    Metabolism of lipids and lipoproteins GLTPA,ACOT8,PPM1L,PNPLA8,MED9,AKR1C2,SREBF2,FAAH2B,EBP,PHOSPHO1
    Glycosphingolipid metabolism ARSF,ARSI,ARSD,GLB1L,GLTP,GLTPD1,ARSK,ARSE,NEU4,ARSJ
    Post-translational protein modification GALNT13,RNF2,ADAMTSL4,A4GNT,SPON1A,C8orf84,DHPS,TMED10,DPH3,TMED2
    Metabolism of proteins MBOAT4,BCS1L,NSMCE2,CBX8,CTSG,PAPPA,NAPG,CCT7,ARSD,MPDU1A

    Protein Function

    NEU3 has several biochemical functions, for example, alpha-sialidase activity,exo-alpha-(2->3)-sialidase activity,exo-alpha-(2->6)-sialidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NEU3 itself. We selected most functions NEU3 had, and list some proteins which have the same functions with NEU3. You can find most of the proteins on our site.

    Function Related Protein
    exo-alpha-sialidase activity ST3GAL5L,NEU3.2,NEU3.4,NEU3.5,NEU3.3,NEU1,NEU3.1,NEU4
    exo-alpha-(2->3)-sialidase activity NEU1,NEU2,NEU4
    exo-alpha-(2->6)-sialidase activity NEU4,NEU2,NEU1
    exo-alpha-(2->8)-sialidase activity NEU2,NEU4,NEU1

    Interacting Protein

    NEU3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEU3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEU3.

    Resources

    References

    • Tringali, C; Silvestri, I; et al. Molecular subtyping of metastatic melanoma based on cell ganglioside metabolism profiles. BMC CANCER 14:-(2014).
    • Alghamdi, F; Guo, M; et al. A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes. CELLULAR SIGNALLING 26:1355-1368(2014).

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