NDUFS8
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Official Full Name
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) -
Overview
This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome. -
Synonyms
NDUFS8;NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase);NADH dehydrogenase (ubiquinone) Fe S protein 8 (23kD) (NADH coenzyme Q reductase);NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial;CI 23k;complex I 23kDa subunit;NADH dehydrogenase [ubiquinone] iron sulfur protein 8;mitochondrial;TYKY;BC021616;CI23KD;MGC101957;MGC37950;MS109;NADH dehydrogenase (ubiquinone) Fe S protein 8, 23kDa (NADH coenzyme Q reductase);NADH ubiquinone oxidoreductase 23 kDa subunit;TYKY subunit;complex I-23kD;NADH-ubiquinone oxidoreductase 23 kDa subunit;CI-23k
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NDUFS8-2991R | Recombinant Rhesus monkey NDUFS8 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| NDUFS8-3892HCL | Recombinant Human NDUFS8 293 Cell Lysate | HEK293 | Human | Non |
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| NDUFS8-2810R | Recombinant Rhesus Macaque NDUFS8 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| NDUFS8-2810R-B | Recombinant Rhesus Macaque NDUFS8 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
NDUFS8 involved in several pathways and played different roles in them. We selected most pathways NDUFS8 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-alcoholic fatty liver disease (NAFLD) | TNF,COX8C,SDHC,NDUFS6,GSK3A,IL6R,PRKAB2,Fasl,MAPK10,NDUFB9 |
| Alzheimers disease | IDE,ITPR2,NDUFB8,APBB1,NDUFA11,NDUFB2,CASP7,GAPDH,APP,BID |
| Parkinsons disease | GNAI3,VDAC1,Atp5g2,NDUFB4,NDUFA10,NDUFV1,APAF1,COX7B2,SLC18A2,UBB |
| Huntingtons disease | POLR2D,NDUFC1,BAX,DNAL1,NDUFA11,ATP5D,NDUFA4,ATP5G3,HIP1,COX7B2 |
| Oxidative phosphorylation | NDUFS3,ATP6V1C1A,COX7B2,ATP6V1AA,ATP6V0A1A,NDUFA1,COX5AA,ATP5O,NDUFA11,NDUFB4 |
| Metabolic pathways | PANK3,AOX1,COQ7,ACSS2,GALNT3,ATP5C1,ST6GALNAC5,CYP26A1,CECR1A,POLR2J2 |
Protein Function
NDUFS8 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,contributes_to NADH dehydrogenase (ubiquinone) activity,NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS8 itself. We selected most functions NDUFS8 had, and list some proteins which have the same functions with NDUFS8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to NADH dehydrogenase (ubiquinone) activity | NDUFS1,NDUFS4 |
| contributes_to NADH dehydrogenase activity | NDUFS7,NDUFS2,NDUFV1 |
| NADH dehydrogenase (ubiquinone) activity | NDUFB10,NDUFB9,NDUFA4,NDUFA3,NDUFAB1,NDUFV1,NDUFC2,NDUFC1,NDUFA7,NDUFV3 |
| metal ion binding | ZFYVE21,PXNA,WEE2,TRIM35-30,PDE4C,RORCA,CYP2P10,ITGA9,ZNF599,UGP2 |
| 4 iron, 4 sulfur cluster binding | CDKAL1,SDHB,RTEL1,ACO2,NDUFV1,NDUFS8B,ACO1,PPAT,MOCS1,RSAD1 |
Interacting Protein
NDUFS8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS8 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS8.
vpr;NDUFA2;MLH1;GEM;NDUFS4;NDUFS5;NDUFS7;NDUFS6;NDUFS3;NDUFV1;NDUFA6;ICT1;NDUFA9;NDUFA11;NDUFAF3;TIMMDC1;NDUFA12
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References
- Triepels, RH; Hanson, BJ; et al. Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns. JOURNAL OF BIOLOGICAL CHEMISTRY 276:8892-8897(2001).
