NDUFS5

  • Official Full Name

    NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)

  • Overview

    This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 1, 4 and 17.

  • Synonyms

    NDUFS5;NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase);NADH dehydrogenase (ubiquinone) Fe S protein 5 (15kD) (NADH coenzyme Q reductase);NADH dehydrogenase [ubiquinone] iron-sulfur protein 5;CI 15k;complex I 51kDa subunit;NADH dehydrogenase [ubiquinone] iron sulfur protein 5;CI-15 kDa;Complex I-15 kDa;NADH-ubiquinone oxidoreductase 15 kDa subunit;NADH:ubiquinone oxidoreductase 15 kDa IP subunit;CI15K;CI-15k

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Cynomolgus
  • E.coli
  • Mammalian Cell
  • HEK293
  • His
  • Non
  • His&Fc&Avi
  • GST

    Involved Pathway

    NDUFS5 involved in several pathways and played different roles in them. We selected most pathways NDUFS5 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolic pathways ME3,NDUFS8,ATP6V0E,CTH,GALNT6,ATP6V0A1,PIK3C2B,GPAM,SQLE,ST3GAL1
    Oxidative phosphorylation ATP6V1A,NDUFS3,COX5AA,NDUFA13,NDUFA10,NDUFB7,ATP5E,ATP6V0A2B,ATP5A1,NDUFA4L
    Non-alcoholic fatty liver disease (NAFLD) CEBPA,DDIT3,COX7A1,RELA,TGFB1,Casp3,SDHB,BID,IL-8,LEPR
    Alzheimers disease MME,UQCR11,COX5A,UQCRB,ITPR1,GNAQ,ATP5E,BACE1,TNF,PPP3CC
    Parkinsons disease LRRK2,NDUFB2,ATP5A1,NDUFS6,NDUFA1,COX8C,UQCRFS1,UBE2J2,NDUFA7,NDUFC2-KCTD14
    Huntingtons disease NDUFA11,PLCB3,DCTN1,ATP5G1,NDUFA9,NDUFB5,CASP9,DNAL4,ATP5H,VDAC1

    Protein Function

    NDUFS5 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS5 itself. We selected most functions NDUFS5 had, and list some proteins which have the same functions with NDUFS5. You can find most of the proteins on our site.

    Function Related Protein
    NADH dehydrogenase (ubiquinone) activity NDUFV3,NDUFS1,NDUFV1,NDUFS7,NDUFB7,NDUFAB1,NDUFB9,NDUFA4,NDUFC2,NDUFS2

    Interacting Protein

    NDUFS5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS5 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS5.

    NDUFA2;NDUFA6;NDUFAF1;NR4A2;NDUFS8;COX7A2L;NDUFS4;NDUFB5;NDUFS7;NDUFS2;NDUFS6;NDUFS3;NDUFB6;NDUFB4;NDUFB8;NDUFA7

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