NDUFS3
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Official Full Name
NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -
Overview
This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency. -
Synonyms
NDUFS3;NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase);NADH dehydrogenase (ubiquinone) Fe S protein 3 (30kD) (NADH coenzyme Q reductase);NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial;CI 30;comp
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- T7
- Non
- Avi
- Fc
Involved Pathway
NDUFS3 involved in several pathways and played different roles in them. We selected most pathways NDUFS3 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-alcoholic fatty liver disease (NAFLD) | COX5A,NR1H3,PIK3R3,IRS1,PRKAG1,MAPK9,AKT2,COX4I2,COX6B2,BID |
| Parkinsons disease | COX7A1,NDUFC1,UBA1,COX8C,ATP5G3,SEPT5,NDUFA6,COX7A2,UQCR10,MT-ND4 |
| Oxidative phosphorylation | Atp5k,COX5AA,NDUFS2,COX6B2,UQCRC2B,NDUFB1,ATP5S,ATP4A,SDHA,MT-ATP6 |
| Huntingtons disease | COX7C,HIP1,NDUFB5,DCTN2,NDUFB3,PLCB2,UCP1,SLC25A5,EP300,VDAC2 |
| Alzheimers disease | MAPK3,NDUFA11,ITPR2,NDUFC2,RYR3,ATP5G1,APOE,ATP5D,GSK3B,ATP5O |
| Metabolic pathways | RRM2,PIGC,GBE1,RRM2B,GALNT2,SGPL1,CYP4F3,PNPLA2,SEPHS2,B4GALT2 |
Protein Function
NDUFS3 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity,NADH dehydrogenase activity,electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS3 itself. We selected most functions NDUFS3 had, and list some proteins which have the same functions with NDUFS3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADH dehydrogenase (ubiquinone) activity | NDUFB10,NDUFB3,NDUFA3,NDUFV3,NDUFS8,NDUFS4,NDUFA5,NDUFA7,NDUFC2-KCTD14,NDUFV2 |
| electron carrier activity | COX7A3,GCDH,ACAD9,ME2,QDPR,ACADL,NOX4,AKR7A2,PTGESL,ADH5 |
| protein binding | TMEM106B,PTK7,STARD13,RBP4,Txn1,TMEM199,FAM9B,KRTAP8-1,MYBPC3,ANXA4 |
| NADH dehydrogenase activity | NDUFA9A,NDUFA13,NDUFA9 |
Interacting Protein
NDUFS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS3.
NDUFS2;NDUFA2;NDUFAF3;MT-ND6;VCAM1
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References
- Massoz, S; Larosa, V; et al. Inactivation of genes coding for mitochondrial Nd7 and Nd9 complex I subunits in Chlamydomonas reinhardtii. Impact of complex I loss on respiration and energetic metabolism. MITOCHONDRION 19:365-374(2014).
- Boyle, KE; Hwang, H; et al. Gestational Diabetes Is Characterized by Reduced Mitochondrial Protein Expression and Altered Calcium Signaling Proteins in Skeletal Muscle. PLOS ONE 9:-(2014).
