NDUFS2
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Official Full Name
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -
Overview
The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NDUFS2;NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase);NADH dehydrogenase (ubiquinone) Fe S protein 2 (49kD) (NADH coenzyme Q reductase);NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial;CI 49;complex I 49kDa subunit;NADH dehydrogenase [ubiquinone] iron sulfur protein 2;mitochondrial;CI 49kD;CI-49kD;Complex I 49kD;Complex I-49kD;NADH dehydrogenase [ubiquinone] iron sulfur protein 2, mitochondrial;NADH dehydrogenase [ubiquinone] iron-sulfur protein 2;NADH ubiquinone oxidoreductase 49 kDa subunit;NADH-ubiquinone oxidoreductase 49 kDa subunit;NDUS2_HUMAN;OTTHUMP00000032241;NADH-ubiquinone oxidoreductase NDUFS2 subunit;complex 1, mitochondrial res;CI-49
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- His
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
NDUFS2 involved in several pathways and played different roles in them. We selected most pathways NDUFS2 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Huntingtons disease | COX5A,COX4I1,COX6A1,COX7A2,NDUFA7,DNAI1,NDUFS6,POLR2C,ATP5G3,SDHB |
| Alzheimers disease | NDUFS4,CAPN2,BAD,APP,ATP5D,ATP5B,NDUFC1,Casp3,NDUFS1,NDUFC2 |
| Parkinsons disease | ATP5D,GNAI2,UQCR11,UBA1,PRKACB,PARK2,UQCRC1,NDUFA3,SNCA,UBB |
| Metabolic pathways | PFKP,NOS2B,CYP3A7,PHYKPL,PAFAH1B1,HMGCR,AGXT2,NDUFAB1,COX8A,IMPDH1B |
| Oxidative phosphorylation | ATP6V1G1,NDUFB3,COX6A2,SDHB,ATP5B,NDUFA3,NDUFS4,ATP6V1E2,ATP6V1AA,COX17 |
| Non-alcoholic fatty liver disease (NAFLD) | LEP,NDUFA11,GSK3A,PIK3CG,CYCS,UQCRB,CDC42,UQCR11,ADIPOQ,INS2 |
Protein Function
NDUFS2 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,NAD binding,NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS2 itself. We selected most functions NDUFS2 had, and list some proteins which have the same functions with NDUFS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| quinone binding | HHIPL1,ETFDH,VKORC1L1,VKORC1,AMOTL1,AOC1,TP53I3,SQRDL,AOC3,HHIP |
| protein binding | ERP44,KIF18A,USP34,CSK,PLOD3,DPM1,MIS12,FMR1,HDAC3,C2orf29 |
| NADH dehydrogenase (ubiquinone) activity | NDUFS5,NDUFV3,NDUFA4,NDUFA13,NDUFS1,NDUFB2,NDUFB3,NDUFC2,NDUFS7,NDUFA5 |
| 4 iron, 4 sulfur cluster binding | ISCA1,NFU1,CDKAL1,DEM1,DPYDB,DPYD,PPAT,DNA2,PRIM2,ACO2 |
| contributes_to NADH dehydrogenase activity | NDUFV1,NDUFS8,NDUFS7 |
| ubiquitin protein ligase binding | PIAS1,TRIB2,PINK1,VCL,SMAD5,KCNH2,ASB4,XBP1,OTUB1,SPOP |
| NAD binding | CTBP2L,BDH2,HPGD,UGDH,GLYR1,HSD11B2,PARP1,GPD1B,NNT,SORD |
| electron carrier activity | ME1,AOX4,GSR,IDH3B,ACOX3,FDX1L,COX7A1,NDUFS3,GLRX5,AKR7A3 |
| metal ion binding | PHF23B,PCK2,ZSCAN2,RC3H2,FAM170A,ZNF556,ZNF688,IMPDH1A,REST,ZBTB8B |
Interacting Protein
NDUFS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS2.
NDUFS3;NDUFA9;NDUFAF3;MYC;NDUFV2;NDUFA2;DMWD;SQSTM1;EGR2
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