NDUFC2
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Official Full Name
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa -
Overview
NADH dehydrogenase1 subunit C2 is an enzyme that in humans is encoded by the NDUFC2 gene. -
Synonyms
NDUFC2;NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa;NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2 (14.5kD, B14.5b);NADH dehydrogenase [ubiquinone] 1 subunit C2;B14.5b;complex I subunit B14.5b;HLC 1;human lung cancer oncogene 1;CI-B14.5b;Complex I B14.5b;Complex I-B14.5b;HLC-1;HLC1;Human lung cancer oncogene 1 protein;NADH dehydrogenase ubiquinone 1 subunit C2;NADH ubiquinone oxidoreductase subunit B14.5b;NADH-ubiquinone oxidoreductase subunit B14.5b;NDUC2_HUMAN;OTTHUMP00000233778;OTTHUMP00000233779;OTTHUMP00000233781;NADHDH2
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Chicken
- Cynomolgus
- Pongo Pygmaeus
- Gorilla gorilla gorilla (Western lowland gorilla)
- Mus musculus
- Bovine
- Macaca fascicularis
- Pan troglodytes
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
NDUFC2 involved in several pathways and played different roles in them. We selected most pathways NDUFC2 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | ATP6V1AA,NDUFA4L,PPA1A,COX10,ATP5G3,SDHA,ATP5J2,SDHDA,ATP5I,ATP5F1 |
| Metabolic pathways | HYAL3,ATP6V0CA,MGAT3A,ACSS1,DHDPSL,LPIN3,KL,SDHA,PCK2,KLF15 |
| Parkinsons disease | NDUFB1,SLC6A3,UBE2J1,NDUFV3,SLC18A2,NDUFB6,mt-Atp8,ATP5D,PINK1,ATP5O |
| Alzheimers disease | NDUFA3,COX6C,LPL,ITPR2,NDUFV1,PPP3CA,ADAM17,GRIN1,PLCB4,ERN1 |
| Huntingtons disease | COX7C,GRIN1,NDUFA12,PLCB3,DNAH14,SOD1,NDUFB5,RCOR1,EP300,PPIF |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFS4,PRKAG2,GSK3A,Fasl,PRKAA1,INS1,PRKAG3,KCNA3,NDUFB6,NDUFS2 |
Protein Function
NDUFC2 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFC2 itself. We selected most functions NDUFC2 had, and list some proteins which have the same functions with NDUFC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADH dehydrogenase (ubiquinone) activity | NDUFS8,NDUFS5,NDUFA2,NDUFAF2,NDUFA3,NDUFB1,NDUFAB1,NDUFS7,NDUFB10,NDUFA4 |
Interacting Protein
NDUFC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFC2.
NDUFA2;NDUFA6;NDUFA13;COA3
Resources
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References
- Gershoni, M; Levin, L; et al. Disrupting Mitochondrial-Nuclear Coevolution Affects OXPHOS Complex I Integrity and Impacts Human Health. GENOME BIOLOGY AND EVOLUTION 6:2665-2680(2014).
- Nitert, MD; Dayeh, T; et al. Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes. DIABETES 61:3322-3332(2012).
