NDUFB5
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Official Full Name
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -
Overview
The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NDUFB5;NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa;NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 (16kD, SGDH);NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial;CI SGDH;complex I SGDH subunit;MGC12314;SGDH;Complex I SGDH;DKFZp686N02262;FLJ30597;MGC111204;NADH dehydrogenase (ubiquinone) 1 beta subcomplex 5;NADH dehydrogenase (ubiquinone) 1 beta subcomplex 5 16kDa;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5;NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5 mitochondrial;NADH ubiquinone oxidoreductase SGDH subunit;complex I-SGDH;OTTHUMP00000212214;OTTHUMP00000212215;OTTHUMP00000212257;OTTHUMP00000212259;NADH-ubiquinone oxidoreductase SGDH subunit;CISGDH
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Zebrafish
- Cynomolgus
- Pan troglodytes
- Mus musculus
- Macaca fascicularis
- Gorilla gorilla gorilla (Western lowland gorilla)
- Pongo Pygmaeus
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
- His&SUMO
Involved Pathway
NDUFB5 involved in several pathways and played different roles in them. We selected most pathways NDUFB5 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFB5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-alcoholic fatty liver disease (NAFLD) | UQCRC1,COX7A1,NDUFB8,UQCRQ,ADIPOR1,NDUFC2,NFKB1,INSR,NDUFV3,SDHC |
| Parkinsons disease | NDUFA3,NDUFA10,MT-ND4,PRKACB,APAF1,UQCRFS1,ATP5C1,ATP5E,SLC18A1,GNAL |
| Oxidative phosphorylation | COX5AA,COX8C,ATP6V0A4,SDHB,ATP5E,ATP6AP1B,NDUFAB1,COX7A2A,ATP6V1A,NDUFA12 |
| Huntingtons disease | NDUFS4,SDHA,UCP1,ATP5D,COX4I1,REST,COX6B2,COX7A1,UQCRFS1,NDUFV3 |
| Alzheimers disease | NDUFV1,CAPN2,ATP5A1,CALML5,NDUFA3,UQCRB,PSEN2,NDUFB1,MAPT,NDUFB7 |
| Metabolic pathways | ASPA,IDH3G,CBR1,ATP5J2,PLA2G7,SGMS2,UMPS,CKM,HYKK.2,PTGES2 |
Protein Function
NDUFB5 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFB5 itself. We selected most functions NDUFB5 had, and list some proteins which have the same functions with NDUFB5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADH dehydrogenase (ubiquinone) activity | NDUFV2,NDUFS5,NDUFC1,NDUFS1,NDUFA2,NDUFB10,NDUFC2-KCTD14,NDUFV1,NDUFC2,NDUFA4 |
Interacting Protein
NDUFB5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFB5 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFB5.
NDUFA2;NDUFS5;SYNCRIP;NDUFA6;Ncstn;Ruvbl1;NDUFA9;ATG16L1;SAMD1;NDUFA11;NCSTN;SORT1;TIMMDC1;NDUFA12
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