NDUFB3
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Official Full Name
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -
Overview
The multisubunit NADH:ubiquinone oxidoreductase (complex I) is the first enzyme complex in the electron transport chain of mitochondria. See NDUFA2 (MIM 602137). -
Synonyms
NDUFB3;NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa;NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3 (12kD, B12);NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3;B12;complex I B12 subunit;CI B12;Complex I B12;NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 12kDa;NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3;NADH ubiquinone oxidoreductase B12 subunit;NDUFB 3;CI-B12;complex I-B12;OTTHUMP00000163716;OTTHUMP00000206488;OTTHUMP00000206489;NADH-ubiquinone oxidoreductase B12 subunit
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Pan troglodytes
- Pongo Pygmaeus
- Mus musculus
- Gorilla gorilla gorilla (Western lowland gorilla)
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
NDUFB3 involved in several pathways and played different roles in them. We selected most pathways NDUFB3 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Huntingtons disease | HDAC1,DNALC1,PPARG,POLR2A,ATP5F1,NDUFV1,IFT57,COX7B,HIP1,ATP5O |
| Non-alcoholic fatty liver disease (NAFLD) | PIK3CD,NDUFAB1,NDUFA6,IRS1,FASLG,PIK3R3,BAX,LEPR,SREBF1,PRKAA2 |
| Oxidative phosphorylation | ATP6V1AA,NDUFA3,NDUFB11,Atp5k,SDHDA,NDUFA2,NDUFA8,NDUFA6,NDUFB2,ctaG |
| Alzheimers disease | UQCR11,COX7A2L,CAPN2,EIF2AK3,NDUFA12,PLCB2,NDUFA2,CDK5R1,UQCRC1,NDUFS7 |
| Parkinsons disease | UBE2J2,VDAC3,NDUFS2,UCHL1,UQCRQ,ATP5O,CASP9,COX7A2L,NDUFB8,NDUFV2 |
| Metabolic pathways | GLS,ALDH1A3,INPP4AB,PCK1,CYP4F14,ASL,POC1BL,MTMR7,SYNJ1,KMO |
Protein Function
NDUFB3 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFB3 itself. We selected most functions NDUFB3 had, and list some proteins which have the same functions with NDUFB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADH dehydrogenase (ubiquinone) activity | NDUFA9,NDUFA13,NDUFB1,NDUFS2,NDUFV1,NDUFA10,NDUFV2,NDUFB8,NDUFS3,NDUFA3 |
Interacting Protein
NDUFB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFB3.
NDUFA2;ATP5C1;NDUFA6;NDUFA9;NDUFA11;NDUFA13;NDUFA12
Resources
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References
- Haack, TB; Haberberger, B; et al. Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing. JOURNAL OF MEDICAL GENETICS 49:277-283(2012).
- Calvo, SE; Compton, AG; et al. Molecular Diagnosis of Infantile Mitochondrial Disease with Targeted Next-Generation Sequencing. SCIENCE TRANSLATIONAL MEDICINE 4:-(2012).
