NDUFA1
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Official Full Name
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -
Overview
The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. -
Synonyms
NDUFA1;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 (7.5kD, MWFE);NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1;CI MWFE;complex I MWFE subunit;MWFE;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex;1 (7.5kD;MWFE);NADH:ubiquinone oxidoreductase (complex 1);type I dehydrogenase;Complex I MWFE;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 1 7.5kDa;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 1;NADH ubiquinone oxidoreductase (complex 1);NADH ubiquinone oxidoreductase MWFE subunit;NDUFA 1;ZNF 183;ZNF183;complex I-MWFE;OTTHUMP00000023930;NADH oxidoreductase subunit MWFE;NADH-ubiquinone oxidoreductase MWFE subu;CI-MWFE
Recombinant Proteins
- Mouse
- Rhesus macaque
- Zebrafish
- Chicken
- Human
- Mus musculus
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
NDUFA1 involved in several pathways and played different roles in them. We selected most pathways NDUFA1 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | ATF6,NDUFS3,NDUFA13,NDUFB3,mt-Atp8,ERN1,COX8C,UQCRC1,NDUFA8,NDUFB1 |
| Huntingtons disease | COX4I1,mt-Atp8,PPIF,NDUFB10,TP53,NDUFA10,UQCRC2,NDUFS8,POLR2A,POLR2D |
| Non-alcoholic fatty liver disease (NAFLD) | CASP8,UQCRQ,PIK3R2,TNFRSF1A,AKT1,PPARA,EIF2AK3,ADIPOQ,NDUFA11,UQCRC2 |
| Oxidative phosphorylation | ATP5G3A,UQCR11,ATP5L,COX10,NDUFA9A,NDUFB5,ATP5O,ATP5A1,ATP6V0A2B,ATP6V0A2 |
| Metabolic pathways | PFKMB,PGS1,PLCD4,SMPD5,CYP2C38,TRIT1,FECH,GALNTL4,PNP,POLR3K |
| Parkinsons disease | GNAI2,COX5A,NDUFB8,COX6B2,NDUFA12,NDUFS7,COX6A2,PRKACA,NDUFB2,NDUFB9 |
Protein Function
NDUFA1 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFA1 itself. We selected most functions NDUFA1 had, and list some proteins which have the same functions with NDUFA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADH dehydrogenase (ubiquinone) activity | NDUFS2,NDUFA7,NDUFV2,NDUFB8,NDUFA2,NDUFA12,NDUFS6,NDUFS5,NDUFS4,NDUFA8 |
Interacting Protein
NDUFA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFA1.
GOLGB1;TRIM63;SMURF2;NDUFA6
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References
- Martin, DA; Marona-Lewicka, D; et al. Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia. NEUROPHARMACOLOGY 83:1-8(2014).
- Salehi, MH; Kamalidehghan, B; et al. Gene Expression Profiling of Mitochondrial Oxidative Phosphorylation (OXPHOS) Complex I in Friedreich Ataxia (FRDA) Patients. PLOS ONE 9:-(2014).
