NDC80
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Official Full Name
NDC80 kinetochore complex component -
Overview
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011] -
Synonyms
NDC80;NDC80 kinetochore complex component;HEC;HEC1;TID3;KNTC2;HsHec1;hsNDC80;kinetochore protein NDC80 homolog;kinetochore associated 2;kinetochore protein Hec1;kinetochore-associated protein 2;highly expressed in cancer protein;retinoblastoma-associated protein HEC;NDC80 kinetochore complex component homolog;NDC80 homolog, kinetochore complex component;highly expressed in cancer, rich in leucine heptad repeats
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Chicken
- Cynomolgus
- E.coli
- Mammalian Cell
- HEK293
- Mamanlian cells
- Wheat Germ
- HEK293T
- His
- Myc&DDK
- Non
- Flag
- His&Fc&Avi
- GST
Involved Pathway
NDC80 involved in several pathways and played different roles in them. We selected most pathways NDC80 participated on our site, such as Aurora B signaling,Cell Cycle,Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with NDC80 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| M Phase | NIPBLA,TMPO,CDCA8,CENPH,CLIP1,SKA2,PMF1,NDEL1,KIF18A,CDCA5 |
| Mitotic Metaphase and Anaphase | CENPH,NDEL1,ANKLE2,CENPK,INCENP,MIS12,CENPI,PDS5A,SPDL1,SPC25 |
| Cell cycle | MAPRE1A,ZBTB17,CCNE1,DULLARD,PDS5B,YWHAG1,E2F5,CDC14B,SMAD3B,ARPP19B |
| Cell Cycle, Mitotic | CEP135,DYRK1A,PANE1,CENPE,AHCTF1,TSGA14,CDKN2C,CEP164,DCTN2,PHF8 |
| PLK1 signaling events | SPC24,BORA,TCTN2,TPX2,ECT2,TPT1,ERCC6L,PLK1S1 |
| Mitotic Prometaphase | CENPC1,RCC2,SMC4,CENPQ,AHCTF1,CENPO,WAPAL,SGOL1,SMC2,CDCA8 |
| Mitotic Anaphase | ANKLE2,CDCA5,B9D2,PANE1,NUF2,SGOL1,ZWILCH,LEMD3,AHCTF1,VRK1 |
| Aurora B signaling | RACGAP1,NSUN2,INCENP,TACC1,AURKB,PEBP1,NPM1,KIF20A,CBX5,KIF2C |
Protein Function
NDC80 has several biochemical functions, for example, identical protein binding,protein binding,structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by NDC80 itself. We selected most functions NDC80 had, and list some proteins which have the same functions with NDC80. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | Reln,JAM3,PFTK1,CTDSP2,MC4R,MYL12B,LMO3,CAMK2G,MIS12,CASP2 |
| structural constituent of cytoskeleton | ARPC1B,TUBB1,ACTL7B,YEATS4,EPB42,TUBA4L,EPB41L3,TUBA1C,ACTR2,TUBA8L3 |
| identical protein binding | DPP9,NLRC4,BNIP3L,AGXT2,ASS1,PLIN5,PPP5C,MCPH1,YWHAZ,L1CAM |
Interacting Protein
NDC80 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDC80 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDC80.
NUF2;ZWINT
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References
- Boeckmann, L; Takahashi, Y; et al. Phosphorylation of centromeric histone H3 variant regulates chromosome segregation in Saccharomyces cerevisiae. MOLECULAR BIOLOGY OF THE CELL 24:2034-2044(2013).
- Sun, SC; Zhang, DX; et al. Ndc80 Regulates Meiotic Spindle Organization, Chromosome Alignment, and Cell Cycle Progression in Mouse Oocytes. MICROSCOPY AND MICROANALYSIS 17:431-439(2011).
