NCOR2
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Official Full Name
nuclear receptor corepressor 2 -
Overview
SMRT is 1495 amino acids and contains an 8 amino acid sequence that is not present in SMRTe (SMRT-extended), which contains 2514 amino acids. SMRTe contains an N-terminal sequence spanning over 1,000 amino acids that is not present in SMRT, but that shows significant similarity with N-CoR. SMRTe expression is regulated during cell cycle progression, suggesting a role for SMRTe in the regulation of cycle-specific gene expression in diverse signaling pathways. -
Synonyms
NCOR2;nuclear receptor corepressor 2;nuclear receptor co repressor 2;CTG26;SMRT;SMRTE;TNRC14;TRAC 1;CTG repeat protein 26;T3 receptor-associating factor;thyroid-, retinoic-acid-receptor-associated corepressor;silencing mediator for retinoid and thyroid hormone receptors;TRAC;TRAC1;N-CoR2;TRAC-1;SMAP270;SMRTE-tau;FLJ25011
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NCOR2-1619Z | Recombinant Zebrafish NCOR2 | Mammalian Cell | Zebrafish | His |
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| NCOR2-1889H | Recombinant Human Nuclear Receptor Corepressor 2, GST-tagged | E.coli | Human | GST | 395-489 a.a. |
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| Kit-0618 | NCOR2 Gene Knockdown Quantification Kit | Non |
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| NCOR2-1759H | Recombinant Human NCOR2 protein(1-312aa), His-tagged | E.coli | Human | His | 1-312aa |
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Involved Pathway
NCOR2 involved in several pathways and played different roles in them. We selected most pathways NCOR2 participated on our site, such as Notch signaling pathway,Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCOR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epstein-Barr virus infection | POLR3D,POLR2L,POLR3K,TRAF5,HDAC4,RELA,IKBKG,PSMD4,PSMC4,GTF2B |
| Notch signaling pathway | DLB,MFAP5,TUBB3,PSEN2,CNTN6,NUMBL,ADAM17A,RBPJ,MFNG,DLL3 |
Protein Function
NCOR2 has several biochemical functions, for example, DNA binding,Notch binding,histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCOR2 itself. We selected most functions NCOR2 had, and list some proteins which have the same functions with NCOR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | KAT2B,JUNBB,SIRT2,ENPP2,HDAC3,TRIB2,GTF2B,KEAP1,NR0B1,Ar |
| transcription corepressor activity | HSBP1,BATF3,KCNIP3,NR0B1,NR1H4,GPS2,ZHX3,TAF9B,MXD1,BRD7 |
| DNA binding | PBX1,NR6A1B,AIFM2,NUPR1,ZFP639,OTPA,ARHGAP35,ZBTB32,THAP10,NAT14 |
| protein binding | STAM2,TOM1L1,SPEF1,CENPK,RUSC1-AS1,TUFM,SPC25,ZWILCH,ZNF664-FAM101A,CASP14 |
| protein N-terminus binding | TDRD7,NCOA1,ATM,ALG2,MYO7A,KCNB1,SDCBP,CSNK2A2,PARP1,NPAT |
| ligand-dependent nuclear receptor binding | SMARCE1,ISL1,MED1,PROX1,NR1H4,NCOA3,SMARCD3,ARID1A,TADA3,UBA3 |
| histone deacetylase binding | HIC1,TFAP4,CBX5,PARK2,HDAC6,MAGEA2B,GLI3,RBBP4,SIX3,RAD9A |
| Notch binding | NOTCH4,DTX1,SNW1,DLL1,DLL4,JAG2,NOTCH1,JAG2B,GALNT11,NOV |
Interacting Protein
NCOR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCOR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCOR2.
NCOR2 Related Signal Pathway
Resources
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References
- Carlberg, C; Dunlop, TW; et al. The impact of chromatin organization of vitamin D target genes. ANTICANCER RESEARCH 26:2637-2645(2006).
- Widerak, M; Ghoneim, C; et al. The aryl hydrocarbon receptor activates the retinoic acid receptor alpha through SMRT antagonism. BIOCHIMIE 88:387-397(2006).
