NCOA5
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Official Full Name
nuclear receptor coactivator 5 -
Overview
This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined. -
Synonyms
NCOA5;nuclear receptor coactivator 5;bA465L10.6;CIA;coactivator independent of AF 2;MGC28864;KIAA1637;NCoA 5;OTTMUSP00000001057;RP23-61O3.13;NCoA-5;coactivator independent of AF-2
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NCOA5-1215H | Recombinant Human NCOA5, GST-tagged | E.coli | Human | GST | 112-384aa | |
| NCOA5-10484M | Recombinant Mouse NCOA5 Protein | Mammalian Cell | Mouse | His |
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| NCOA5-1309Z | Recombinant Zebrafish NCOA5 | Mammalian Cell | Zebrafish | His |
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| NCOA5-2959R | Recombinant Rhesus monkey NCOA5 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| NCOA5-2778R | Recombinant Rhesus Macaque NCOA5 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| NCOA5-2778R-B | Recombinant Rhesus Macaque NCOA5 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| NCOA5-5947M | Recombinant Mouse NCOA5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NCOA5-5947M-B | Recombinant Mouse NCOA5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
NCOA5 involved in several pathways and played different roles in them. We selected most pathways NCOA5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NCOA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
NCOA5 has several biochemical functions, for example, chromatin binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCOA5 itself. We selected most functions NCOA5 had, and list some proteins which have the same functions with NCOA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | ZFP143,UBE2T,OVOL2,ATAD2B,AAAS,EOMES,CHAF1B,KAT2A,CUX1,POU4F2 |
| poly(A) RNA binding | TPR,MADD,RPL18A,ZFP768,NCBP1,SRP14,SERBP1,RBM38,RPL13,CSDA |
| protein binding | MUTED,MCCC1,PLG,EIF4EBP1,APAF1,EDAR,AGBL4,ATXN7,AKAP5,SLAMF1 |
Interacting Protein
NCOA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCOA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCOA5.
Nr1d2;ESR1;TSC22D1;CDC37;cheY;AIM2;HNRNPA1;PPP1CC;MATR3;Fus;PPP1CB;PYHIN1;Srsf1;Taf15;PEO1;MPHOSPH8;MAP1LC3B;MAP1LC3A
Resources
Related Services
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References
- Geier, A; Martin, IV; et al. Hepatocyte nuclear factor-4 alpha is a central transactivator of the mouse Ntcp gene. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 295:G226-G233(2008).
- Liang, JJ; Wang, ZX; et al. The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors. JOURNAL OF UROLOGY 177:1918-1922(2007).
