NALCN
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Official Full Name
sodium leak channel, non-selective -
Overview
NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is;responsible for the neuronal background sodium leak conductance (Lu et al., 2007 (PubMed 17448995)). -
Synonyms
NALCN;sodium leak channel, non-selective;VGCNL1, voltage gated channel like 1;sodium leak channel non-selective protein;bA430M15.1;CanIon;voltage gated channel like 1;voltage gated channel-like protein 1;four repeat voltage-gated ion channel;VGC
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NALCN-2331Z | Recombinant Zebrafish NALCN | Mammalian Cell | Zebrafish | His |
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| NALCN-3894R | Recombinant Rat NALCN Protein | Mammalian Cell | Rat | His |
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| NALCN-3553R | Recombinant Rat NALCN Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| NALCN-3553R-B | Recombinant Rat NALCN Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
NALCN involved in several pathways and played different roles in them. We selected most pathways NALCN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NALCN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
NALCN has several biochemical functions, for example, ion channel activity,voltage-gated calcium channel activity,voltage-gated ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NALCN itself. We selected most functions NALCN had, and list some proteins which have the same functions with NALCN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| voltage-gated calcium channel activity | CACNA1BA,CACNA2D4,CACNA2D1,CACNG1A,CACNG2B,NCS1,CACNA1SA,OPRM1,ITGAV,TPC3 |
| ion channel activity | KCNA6A,TRPV5,ASIC4,KCNV2,TPCN1,RYR1B,GRIA2A,CHRNA10A,CACNA1C,KCNQ2A |
| voltage-gated ion channel activity | CX35B,CACNA1DA,KCNJ11L,KCNIP4,KCNIP1,TMEM37,CALHM1,KCNS3B,KCNC3A,ANO6 |
Interacting Protein
NALCN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NALCN here. Most of them are supplied by our site. Hope this information will be useful for your research of NALCN.
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References
- Chong, JX; McMillin, MJ; et al. De Novo Mutations in NALCN Cause a Syndrome Characterized by Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay. AMERICAN JOURNAL OF HUMAN GENETICS 96:462-473(2015).
- Wu, HH; Shabala, L; et al. Durum and Bread Wheat Differ in Their Ability to Retain Potassium in Leaf Mesophyll: Implications for Salinity Stress Tolerance. PLANT AND CELL PHYSIOLOGY 55:1749-1762(2014).
