NAB2
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Official Full Name
NGFI-A binding protein 2 (EGR1 binding protein 2) -
Overview
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. -
Synonyms
NAB2;NGFI-A binding protein 2 (EGR1 binding protein 2);NGFI-A-binding protein 2;MADER;EGR1 binding protein 2;EGR-1-binding protein 2;melanoma-associated delayed early response protein;MGC75085
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- Wheat Germ
- Mammalian Cells
- HEK293
- Non
- His
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NAB2-28773TH | Recombinant Human NAB2 | Wheat Germ | Human | Non | 105 amino acids |
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| NAB2-2939R | Recombinant Rhesus monkey NAB2 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| NAB2-6425Z | Recombinant Zebrafish NAB2 | Mammalian Cells | Zebrafish | His |
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| NAB2-3988HCL | Recombinant Human NAB2 293 Cell Lysate | HEK293 | Human | Non |
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| NAB2-2759R | Recombinant Rhesus Macaque NAB2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| NAB2-2759R-B | Recombinant Rhesus Macaque NAB2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Nab2-4275M | Recombinant Mouse Nab2 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| NAB2-6330H | Recombinant Human NAB2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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Involved Pathway
NAB2 involved in several pathways and played different roles in them. We selected most pathways NAB2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NAB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
NAB2 has several biochemical functions, for example, protein binding,transcription corepressor activity,transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NAB2 itself. We selected most functions NAB2 had, and list some proteins which have the same functions with NAB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | JDP2,KCNRG,COL23A1,NOTCH3,LOX,SLC22A7,STX4A,LPAR1,JAK2,CBX6 |
| transcription factor binding | DACT2,GTF2A1,HDAC7,NFKBIA,MYOD1,FOS,FOXO1,PIAS2,RB1,ARHGEF2 |
| transcription corepressor activity | SAP18,SKIL,NANOG,TFCP2L1,MYBBP1A,AEBP1,ZFPM1,ATN1,YAF2,NR0B2A |
Interacting Protein
NAB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NAB2.
NEDD9;ZMYND19;a8kad6_human;80125;g2xkq0_human
Resources
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References
- Vogels, RJC; Vlenterie, M; et al. Solitary fibrous tumor - clinicopathologic, immunohistochemical and molecular analysis of 28 cases. DIAGNOSTIC PATHOLOGY 9:-(2014).
- Cheah, AL; Billings, SD; et al. STAT6 rabbit monoclonal antibody is a robust diagnostic tool for the distinction of solitary fibrous tumour from its mimics. PATHOLOGY 46:389-395(2014).
