MCM2
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Official Full Name
minichromosome maintenance complex component 2 -
Overview
The MCM2 protein (minichromosome maintenance protein 2) is a 120 kD member of the MCM family that forms a heterotetramer with other family members. This nuclear protein functions in eukaryotic genome replication. MCM2 forms a complex with MCM4, MCM6, and -
Synonyms
MCM2;minichromosome maintenance complex component 2;CCNL1, CDCL1, MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) , minichromosome maintenance deficient (S. cerevisiae) 2 (mitotin);DNA replication licensing factor MCM2;BM28;cdc
Recombinant Proteins
- Chicken
- Human
- Zebrafish
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- Avi&Fc&His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MCM2-1291C | Recombinant Chicken MCM2 | Mammalian Cells | Chicken | His |
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| MCM2-28039TH | Recombinant Human MCM2, His-tagged | E.coli | Human | His | 370-904 a.a. |
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| MCM2-9530Z | Recombinant Zebrafish MCM2 | Mammalian Cells | Zebrafish | His |
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| MCM2-9634M | Recombinant Mouse MCM2 Protein | Mammalian Cells | Mouse | His |
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| MCM2-4420HCL | Recombinant Human MCM2 293 Cell Lysate | HEK293 | Human | Non |
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| MCM2-3212H | Recombinant Human MCM2 protein, His-tagged | E.coli | Human | His | 2-904aa |
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| MCM2-4518H | Recombinant Human MCM2 Protein (Phe657-Phe904), N-His tagged | E.coli | Human | His | Phe657-Phe904 |
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| MCM2-5410M | Recombinant Mouse MCM2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| MCM2-5410M-B | Recombinant Mouse MCM2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MCM2 involved in several pathways and played different roles in them. We selected most pathways MCM2 participated on our site, such as DNA replication,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Replication | RPA4,RPA2,SSBP1,RNASEH2B,FEN1,LIG1,GINS4,GINS1,DNA2,POLA1 |
| Cell cycle | ORC4,CDC23,CEP152,DYNC1I2,E2F5,AURKB,CENPW,CENPH,SMC4,CCNB1 |
Protein Function
MCM2 has several biochemical functions, for example, ATP binding,DNA binding,DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MCM2 itself. We selected most functions MCM2 had, and list some proteins which have the same functions with MCM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | HOXC4A,ASCL1A,H2AFVA,ZFP30,ILF2,ZNF789,ZFP367,SP140L,ZNF446,NKX2-6 |
| metal ion binding | SP9,SDF4,RNF150A,COL9A1,TRIM108,SAP30L,PLAGX,C6AST3,KAT5,CYP2X8 |
| DNA replication origin binding | ORC3L,MCM10,HSPD1,ORC4,ORC4L,MCM5,ORC2L,CDC45 |
| histone binding | RNF168,BRD7,IPO7,UHRF1,USP3,HIST4H4,HIST1H4N,CHD8,HIST1H3C,HIST1H4D |
| ATP binding | TDRD9,SRPK1A,LIG1,P2RX4,GK5,VPS4A,MAP2K7,SMCHD1,TTLL4,HSPA12B |
| protein binding | AGL,ALKBH4,CNOT3,TRPC6,DRD3,PDCD2,ATF4,S100A14,TRIM50,PIN4 |
| DNA helicase activity | MCM3,RAD54B,MCM3L,WRN,RUVBL2,MCM6L,DNA2,IGHMBP2,RECQL5,PIF1 |
Interacting Protein
MCM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCM2.
MCM6;MCM7
Resources
Research Area
Cancer Stem Cell Transcription FactorsNeural Stem Cell Transcription Factors
Other DNA Repair
Related Services
Related Products
References
- Jenson, EG; Baker, M; et al. MCM2/TOP2A (ProExC) immunohistochemistry as a predictive marker in head and neck mucosal biopsies. PATHOLOGY RESEARCH AND PRACTICE 210:346-350(2014).
- Gonzalez, LM; Williamson, I; et al. Cell Lineage Identification and Stem Cell Culture in a Porcine Model for the Study of Intestinal Epithelial Regeneration. PLOS ONE 8:-(2013).
