LYAR
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Official Full Name
Ly1 antibody reactive clone -
Overview
LYAR, also known as Ly1 antibody reactive clone, has been found to regulate the intracellular strength that is stimulated by both T and B cell antigen receptors. It is essential for immune tolerance and certain changes to its function could stimulate the development of autoreactivity. LYAR is important in the immunological synapse and functions to inhibit the T cell response. LYAR is highly expressed in indifferentiated embryonic stem cells and may be important in maintaining the stem cell identity. -
Synonyms
LYAR;Ly1 reactive clone;cell growth-regulating nucleolar protein;protein expressed in male leptotene and zygotene spermatocytes 264;MLZ-264
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- Human
- Mammalian Cell
- E.coli
- Yeast
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&T7
- His&Fc&Avi
- GST
Involved Pathway
LYAR involved in several pathways and played different roles in them. We selected most pathways LYAR participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LYAR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
LYAR has several biochemical functions, for example, metal ion binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LYAR itself. We selected most functions LYAR had, and list some proteins which have the same functions with LYAR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NEFM,KCTD5,MAGEH1,ITGA3,NEDD9,SNIP1,HYAL3,UBC,HBQ1,ATG12 |
| poly(A) RNA binding | ROCK2,POLR2A,IGF2BP3,AKAP8,TRIP6,SAP18,XRCC6,UCHL5,EIF2S1A,EIF4A3 |
| metal ion binding | TRIM71,Acsm2a,OBSCN,STS,FOXP1,ZBTB41,BTR02,TGM1,NUBP2,SP1 |
Interacting Protein
LYAR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LYAR here. Most of them are supplied by our site. Hope this information will be useful for your research of LYAR.
PRKRA;BEND7;SDCBP2;20475405;KPNA6;DKC1;KRT36
Resources
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References
- Miyazawa, N; Yoshikawa, H; et al. Human cell growth regulator Ly-1 antibody reactive homologue accelerates processing of preribosomal RNA. GENES TO CELLS 19:273-286(2014).
- Ju, JY; Wang, Y; et al. Human fetal globin gene expression is regulated by LYAR. NUCLEIC ACIDS RESEARCH 42:9740-9752(2014).
