LRAT
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Official Full Name
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) -
Overview
The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy. -
Synonyms
LRAT;lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase);lecithin retinol acyltransferase;LCA14;MGC33103
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mammalian Cell
- HEK293
- In vitro E. coli expression system
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
LRAT involved in several pathways and played different roles in them. We selected most pathways LRAT participated on our site, such as Retinol metabolism,Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vitamin digestion and absorption | LMBRD1,APOA1,BTD,RBP2,GIF,PNLIP,SLC19A2,SLC19A3,TCN2,SLC23A1 |
| Retinol metabolism | UGT5G1,BCMO1,CYP2B19,CYP2C70,UGT1A3,UGT2B7,RDH10B,CYP3A25,RDH5,DHRS3 |
Protein Function
LRAT has several biochemical functions, for example, phosphatidylcholine-retinol O-acyltransferase activity,retinoic acid binding,retinol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRAT itself. We selected most functions LRAT had, and list some proteins which have the same functions with LRAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| retinol binding | ADH4,ADH7,CRABP1,RBP7,RLBP1,RBP2,C8G,RBP5,RBP3,CRABP2 |
| retinoic acid binding | LCN12,UGT1A3,UGT1A1,UGT1A9,UGT1A2,PTGDSB,SERPINA5,CRABP2A,NR2F2,CRABP1B |
| transferase activity, transferring acyl groups | HHATLA,ZDHHC22,ZDHHC3A,CRATA,ZDHHC23B,GGACT.2,GLYAT,Nat3,AANAT,LPCAT3 |
Interacting Protein
LRAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRAT here. Most of them are supplied by our site. Hope this information will be useful for your research of LRAT.
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References
- Brown, GT; Cash, BG; et al. The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer. PLOS ONE 9:-(2014).
- Nagatsuma, K; Hano, H; et al. Hepatic stellate cells that coexpress LRAT and CRBP-1 partially contribute to portal fibrogenesis in patients with human viral hepatitis. LIVER INTERNATIONAL 34:243-252(2014).
