LPXN
-
Official Full Name
leupaxin -
Overview
The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
LPXN;leupaxin;LDPL;LDLP
Recombinant Proteins
- Rhesus macaque
- Mouse
- Human
- Mammalian Cell
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&T7
- Non
- His&Fc&Avi
- GST
Involved Pathway
LPXN involved in several pathways and played different roles in them. We selected most pathways LPXN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LPXN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
LPXN has several biochemical functions, for example, protein binding,transcription cofactor activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LPXN itself. We selected most functions LPXN had, and list some proteins which have the same functions with LPXN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | FHL1A,CXXC1,ZZEF1,MTF2,NR1D4A,LNPEP,CSRP1,ZYX,RBM20,DDX41 |
| transcription cofactor activity | TRIP13,LDB2A,NFKBIZ,IRF3,ZNF763,AIRE,NMI,NFE2L1,NRG1,TADA2A |
| protein binding | PHOSPHO2-KLHL23,PDGFA,DACT1,FABP5,ZNF792,PDCD10,DZIP1,TMEM93,PTBP3,SRF |
Interacting Protein
LPXN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPXN here. Most of them are supplied by our site. Hope this information will be useful for your research of LPXN.
Hoxa1;9814;LMO1;HOXC9;RUNX1T1;PLEKHN1;DKFZp451B226
Resources
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References
- Dierks, S; von Hardenberg, S; et al. Leupaxin acts on cell adhesion and cytoskeletal remodeling and influences integrin expression in prostate cancer cells. ONCOLOGY RESEARCH AND TREATMENT 37:62-62(2014).
- Dierks, S; Von Hardenberg, S; et al. Leupaxin mediates actin cytoskeletal remodeling by regulating the phosphorylation status of the actin-binding protein caldesmon in prostate cancer cells. EUROPEAN JOURNAL OF CANCER 49:S685-S685(2013).
