LPHN2
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Official Full Name
latrophilin 2 -
Overview
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined. -
Synonyms
LPHN2;latrophilin 2;latrophilin 1 , LPHH1;latrophilin-2;KIAA0786;LEC1;CIRL-2;lectomedin-1;latrophilin 1;latrophilin homolog 1;latrophilin homolog 2 (cow);calcium-independent alpha-latrotoxin receptor 2;CL2;CIRL2;LPHH1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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| LPHN2-3441R | Recombinant Rat LPHN2 Protein | Mammalian Cell | Rat | His |
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| LPHN2-4105C | Recombinant Chicken LPHN2 | Mammalian Cell | Chicken | His |
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| LPHN2-3097R | Recombinant Rat LPHN2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| LPHN2-3097R-B | Recombinant Rat LPHN2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
LPHN2 involved in several pathways and played different roles in them. We selected most pathways LPHN2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LPHN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
LPHN2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by LPHN2 itself. We selected most functions LPHN2 had, and list some proteins which have the same functions with LPHN2. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
LPHN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPHN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPHN2.
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References
- Davydov, II; Fidalgo, S; et al. Prediction of Epitopes in Closely Related Proteins Using a New Algorithm. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 148:869-873(2009).
- Bugli, F; Graffeo, R; et al. Monoclonal antibody fragment from combinatorial phage display library neutralizes alpha-latrotoxin activity and abolishes black widow spider venom lethality, in mice. TOXICON 51:547-554(2008).
