LPCAT1
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Official Full Name
lysophosphatidylcholine acyltransferase 1 -
Overview
Lysophosphatidylcholine (LPC) acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to;phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis (Nakanishi et al., 2006 (PubMed;16704971)). -
Synonyms
LPCAT1;lysophosphatidylcholine acyltransferase 1;acyltransferase like 2 , AYTL2;FLJ12443;LPCAT-1;lysoPAFAT;LPC acyltransferase 1;acyltransferase like 2;acyltransferase-like 2;lysoPC acyltransferase 1;lyso-PAF acetyltransferase;regulated by phos
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- His&GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
LPCAT1 involved in several pathways and played different roles in them. We selected most pathways LPCAT1 participated on our site, such as Glycerophospholipid metabolism,Ether lipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPCAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerophospholipid metabolism | MBOAT1,AGPAT6,DGKD,LYPLA2,PLA2G12B,PNPLA6,PLA2G12A,CHAT,PCYT1A,ADPRM |
| Metabolic pathways | DAD1,HSD17B10,CMBL,COX10,NDST4,BCAT2,PIK3C2A,CDO1,BST1,ATP5J2 |
| Ether lipid metabolism | PLD1A,PLA2G4A,UGT8A,ENPP6,PLA2G2F,EPT1,PPAP2C,PPAP2CB,AGPS,PLB1 |
Protein Function
LPCAT1 has several biochemical functions, for example, 1-acylglycerophosphocholine O-acyltransferase activity,1-alkenylglycerophosphocholine O-acyltransferase activity,1-alkylglycerophosphocholine O-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LPCAT1 itself. We selected most functions LPCAT1 had, and list some proteins which have the same functions with LPCAT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-acylglycerophosphocholine O-acyltransferase activity | LPCAT4,LPCAT3,TAZ,LPCAT2 |
| calcium ion binding | DLC,FBN2B,C1RA,ACTN3,ACTN2B,PKD1L3,LDLR,TMPRSS6,DNER,F2 |
| 1-alkylglycerophosphocholine O-acetyltransferase activity | LPCAT2,LPCAT4 |
Interacting Protein
LPCAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPCAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPCAT1.
ESR1;ILK;Sap25;HIPK4
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References
- Mansilla, F; da Costa, KA; et al. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) overexpression in human colorectal cancer. JOURNAL OF MOLECULAR MEDICINE-JMM 87:85-97(2009).
