LPAR6
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Official Full Name
lysophosphatidic acid receptor 6 -
Overview
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. -
Synonyms
LPAR6;lysophosphatidic acid receptor 6;P2RY5, purinergic receptor P2Y, G protein coupled, 5;P2Y5;G protein coupled purinergic receptor P2Y5;LAH 3;LAH3;LPA receptor 6;LPA-6;LPAR 6;LPAR6_HUMAN;MGC 120358;MGC120358;Oleoyl L alpha lysophosphatidic acid receptor;Oleoyl-L-alpha-lysophosphatidic acid receptor;P 2 RY 5;P2Y purinoceptor 5;Purinergic receptor 5;purinergic receptor P2Y, G protein coupled, 5;RB intron encoded G protein coupled receptor;RB intron encoded G-protein coupled receptor;G-protein coupled purinergic receptor P2Y5;purinergic receptor P2Y, G-protein coupled, 5;purinergic receptor P2Y G protein-coupled protein 5;ARWH1;P2RY5
Recombinant Proteins
- Rhesus macaque
- Rat
- Chicken
- Mouse
- Human
- Mus musculus
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- His&Fc&Avi
Involved Pathway
LPAR6 involved in several pathways and played different roles in them. We selected most pathways LPAR6 participated on our site, such as Phospholipase D signaling pathway,Neuroactive ligand-receptor interaction,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPAR6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | GALR3,GRIN3B,THRB,LHBETA1,CCKAR,MC1R,ADRA2DB,GABRA4,RXFP2,P2RX5 |
| Pathways in cancer | FZD1,PLEKHG5,TGFBR1,GSTP1,STK4,ROCK2,WNT2,EGLN2,BCL2L1,CCNE2 |
| Phospholipase D signaling pathway | AVPR1B,PIK3CD,PLCB1,DGKE,CYTH3,PIK3R5,AGTR1B,GRM2,GAB2,GRM7 |
| PIK-Akt signaling pathway | PRL,FGFR3,COL24A1,PIK3R5,IGF1,IL3,LAMA3,LAMB1,IGF1R,IL4 |
Protein Function
LPAR6 has several biochemical functions, for example, G-protein coupled receptor activity,molecular_function,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LPAR6 itself. We selected most functions LPAR6 had, and list some proteins which have the same functions with LPAR6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | MRGPRD,EMR4,OLFCQ19,MRGPRX1,FPR-RS6,OLFR8,OXGR1A.2,OLFR1002,TMTOPSA,MC5RA |
| signal transducer activity | PPM1A,VMN1R43,CXCR4B,MUL1A,TAAR12C,OLFR24,TAS2R200.2,VAPA,AGTR1A,STAT3 |
| molecular_function | KRT24,CFC1,TNNI2A.2,GM16430,WDR7,DSCR3,AIM1,MHC2DBB,FSD1L,SWT1 |
Interacting Protein
LPAR6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPAR6 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPAR6.
Resources
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References
- Crack, PJ; Zhang, M; et al. Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes. JOURNAL OF NEUROINFLAMMATION 11:-(2014).
- Sayyah, J; Bartakova, A; et al. The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth. JOURNAL OF BIOLOGICAL CHEMISTRY 289:17689-17698(2014).
