LPAR2

  • Official Full Name

    lysophosphatidic acid receptor 2

  • Overview

    This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined.

  • Synonyms

    LPAR2;lysophosphatidic acid receptor 2;EDG4, endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 4;EDG 4;LPA2;LPA receptor 2;LPA receptor EDG4;G protein-coupled receptor;lysophosphatidic acid receptor EDG4;lysophosphat

Recombinant Proteins

  • Rhesus macaque
  • Chicken
  • Human
  • Mus musculus
  • Macaca fascicularis
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • E.coli expression system
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
LPAR2-2540R Recombinant Rhesus monkey LPAR2 Protein, His-tagged Mammalian Cell Rhesus macaque His
LPAR2-3830C Recombinant Chicken LPAR2 Mammalian Cell Chicken His
LPAR2-4021H Recombinant Human LPAR2 Protein, GST-tagged Wheat Germ Human GST
LPAR2-4674HCL Recombinant Human LPAR2 293 Cell Lysate HEK293 Human Non
LPAR2-2360R Recombinant Rhesus Macaque LPAR2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
LPAR2-2360R-B Recombinant Rhesus Macaque LPAR2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
LPAR2-4692HF Recombinant Full Length Human LPAR2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 351 amino acids
LPAR2-4726H Recombinant Human LPAR2 Protein Wheat Germ Human Non
LPAR2-5968HF Recombinant Full Length Human LPAR2 Protein In Vitro Cell Free System Human Full L. 400 amino acids
RFL1395MF Recombinant Full Length Mouse Lysophosphatidic Acid Receptor 2(Lpar2) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length (1-348)
RFL30799HF Recombinant Full Length Human Lysophosphatidic Acid Receptor 2(Lpar2) Protein, His-Tagged E.coli expression system Human His Full L. Full Length (1-351)
RFL5762MF Recombinant Full Length Macaca Fascicularis Lysophosphatidic Acid Receptor 2(Lpar2) Protein, His-Tagged E.coli expression system Macaca fascicularis His Full L. Full Length (1-351)

    Involved Pathway

    LPAR2 involved in several pathways and played different roles in them. We selected most pathways LPAR2 participated on our site, such as Rap signaling pathway,Phospholipase D signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPAR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway PDGFB,ITGB1,PRLR,GYS1,ITGA2B,PIK3CB,FGF12,NGF,PRL,FGF10
    Pathways in cancer GNGT2,FGF17,IGF1,APC2,FN1,HDAC1,TRAF3,GNB3,DAPK3,FGF22
    Neuroactive ligand-receptor interaction P2RX2,GRIA3B,TAAR12C,CHRNB3B,HTR5AL,GABRR3A,HTR5A,PTGER3,PTGFR,TAAR7F
    Rap signaling pathway ID1,Kitl,PDGFRB,MAPK1,GRIN1,FGF1,PRKCI,FGF6,MAP2K2,FGFR4
    Phospholipase D signaling pathway SHC4,SHC3,PDGFD,RHEB,MRAS,CYTH4,GNA12,MAPK1,AVPR1B,AVP

    Protein Function

    LPAR2 has several biochemical functions, for example, G-protein coupled receptor activity,PDZ domain binding,lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LPAR2 itself. We selected most functions LPAR2 had, and list some proteins which have the same functions with LPAR2. You can find most of the proteins on our site.

    Function Related Protein
    lipid binding FER,CRABP1A,PFN4,PITPNM2,HSP12,ACBD6,UNC119.1,BPIFB3,APOA5,CADPS
    lysophosphatidic acid receptor activity LPAR6A,LPAR1,LPAR3,LPAR2B,LPAR2A
    G-protein coupled receptor activity LPAR5,AGTR1A,OPN1MW3,FPR-RS4,NPFFR1L1,OLFCG3,DARC,OR3A2,LPAR2A,GPR20
    protein binding ITK,HSP90B1,DBF4B,ARPIN,SLC26A3,CALCOCO1,RP2,C1orf38,VPS26A,ZNF821
    PDZ domain binding Fzd4,GRASP,DLG1,DLG3,GRIA1,ATP2B4,LLGL2,SNTA1,GNG5,ACVR2A

    Interacting Protein

    LPAR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPAR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPAR2.

    CFTR;SLC9A3R2;ATXN1;BCL6

    Resources

    References

    • Kuriyama, S; Theveneau, E; et al. In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity. JOURNAL OF CELL BIOLOGY 206:113-127(2014).
    • Purvanov, V; Holst, M; et al. G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion. ELIFE 3:-(2014).

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