LMX1B
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Official Full Name
LIM homeobox transcription factor 1, beta -
Overview
This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1;homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the;normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and;dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively;spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
LMX1B;LIM homeobox transcription factor 1, beta;NPS1;LIM homeobox transcription factor 1-beta;LMX-1.2;LIM/homeobox protein 1.2;LIM/homeobox protein LMX1B;LMX1.2;MGC138325;MGC142051
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LMX1B-600H | Recombinant Human LMX1B, His-tagged | E.coli | Human | His | 1-372aa | |
| LMX1B-237H | Recombinant Human LMX1B, His-tagged | E.coli | Human | His | 1-395aa |
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| LMX1B-6910C | Recombinant Chicken LMX1B | Mammalian Cells | Chicken | His |
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| LMX1B-9165M | Recombinant Mouse LMX1B Protein | Mammalian Cells | Mouse | His |
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| LMX1B-383HCL | Recombinant Human LMX1B lysate | HEK293 | Human | Non |
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| LMX1B-5122M | Recombinant Mouse LMX1B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| LMX1B-5122M-B | Recombinant Mouse LMX1B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
LMX1B involved in several pathways and played different roles in them. We selected most pathways LMX1B participated on our site, such as SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with LMX1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| SIDS Susceptibility Pathways | SCN3B,SST,ASCL1,TPH2,PHOX2B,DLX2,ECE1,RUNX3,PKNOX1,CC2D1A |
Protein Function
LMX1B has several biochemical functions, for example, protein binding,sequence-specific DNA binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LMX1B itself. We selected most functions LMX1B had, and list some proteins which have the same functions with LMX1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | RNF112,LMO2,SP140L,RNFT1,ABLIM2,ZDHHC5A,KAT7A,TRIM68,PAPPA2,SCEL |
| transcription factor activity, sequence-specific DNA binding | TFEB,ZBTB25,ZNF45,PRRX2,TAF13,AATF,NFIL3-3,FOXO3B,EF1,SNAPC5 |
| sequence-specific DNA binding | HOXD11,POU2F3,POU5F1,HOXB4,ZNF831,PRRX1,NR2F1,NKX6.2,LONP1,HSFY1 |
| protein binding | BAG1,PTPN4,DYNAP,GPI1,SIGLEC5,GDF7,GPATCH8,XAB2,C12orf43,SYT7 |
Interacting Protein
LMX1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LMX1B here. Most of them are supplied by our site. Hope this information will be useful for your research of LMX1B.
CDC37;LDB1
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References
- Makarev, E; Gorivodsky, M; et al. Islet1 and Its Co-Factor Ldb1 Are Expressed in Quiescent Cells of Mouse Intestinal Epithelium. PLOS ONE 9:-(2014).
- Miller, RL; Knuepfer, MM; et al. FOS-ACTIVATION OF FOXP2 AND LMX1B NEURONS IN THE PARABRACHIAL NUCLEUS EVOKED BY HYPOTENSION AND HYPERTENSION IN CONSCIOUS RATS. NEUROSCIENCE 218:110-125(2012).
