LMX1A
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Official Full Name
LIM homeobox transcription factor 1, alpha -
Overview
Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin (German et al., 1994 -
Synonyms
LMX1A;LIM homeobox transcription factor 1, alpha;LMX1;LIM homeobox transcription factor 1-alpha;LMX1.1;LIM/homeobox protein 1.1;MGC87616
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LMX1A-29601TH | Recombinant Human LMX1A | Wheat Germ | Human | Non | 100 amino acids |
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| LMX1A-3120Z | Recombinant Zebrafish LMX1A | Mammalian Cell | Zebrafish | His |
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| LMX1A-4635C | Recombinant Chicken LMX1A | Mammalian Cell | Chicken | His |
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| LMX1A-291HF | Recombinant Full Length Human LMX1A Protein | In Vitro Cell Free System | Human | Full L. 100 amino acids |
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Involved Pathway
LMX1A involved in several pathways and played different roles in them. We selected most pathways LMX1A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LMX1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
LMX1A has several biochemical functions, for example, protein binding,sequence-specific DNA binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LMX1A itself. We selected most functions LMX1A had, and list some proteins which have the same functions with LMX1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | HOXC8A,ARGFX,TLX3,FOXO3B,HOXC6B,RAB11FIP4A,ISL2A,HOXA9B,ZFP161,NR6A1A |
| protein binding | PDE1B,CASP2,CDK15,PLP2,SPRY4,PATL1,TNPO2,MYBPC1,NMU,NEK8 |
| zinc ion binding | SF3A3,CAPNS2,VDR,MSL2A,FANCL,GATA2A,GATA2,TNP2,ESRRB,ZNF257 |
Interacting Protein
LMX1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LMX1A here. Most of them are supplied by our site. Hope this information will be useful for your research of LMX1A.
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References
- Makarev, E; Gorivodsky, M; et al. Islet1 and Its Co-Factor Ldb1 Are Expressed in Quiescent Cells of Mouse Intestinal Epithelium. PLOS ONE 9:-(2014).
- Hedlund, E; Pruszak, J; et al. Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease. STEM CELLS 26:1526-1536(2008).
