LIMA1

  • Official Full Name

    LIM domain and actin binding 1
  • Overview

    This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated.
  • Synonyms

    LIMA1;LIM domain and actin binding 1;LIM domain and actin-binding protein 1;epithelial protein lost in neoplasm beta;EPLIN;1110021C24Rik;sterol regulatory element binding protein 3;SREBP3;FLJ38853;MGC131726
Cat.# Product name Source (Host) Species Tag Protein Length Price
LIMA1-584H Recombinant Human LIMA1, GST-tagged E.coli Human GST C-term-400aa
LIMA1-4020H Recombinant Human LIMA1 Protein, GST-tagged Wheat Germ Human GST
LIMA1-9194Z Recombinant Zebrafish LIMA1 Mammalian Cell Zebrafish His
LIMA1-4742HCL Recombinant Human LIMA1 293 Cell Lysate HEK293 Human Non
LIMA1-4691HF Recombinant Full Length Human LIMA1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 598 amino acids

    Involved Pathway

    LIMA1 involved in several pathways and played different roles in them. We selected most pathways LIMA1 participated on our site, such as Stabilization and expansion of the E-cadherin adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIMA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Stabilization and expansion of the E-cadherin adherens junction MYO6,KIFC3,PLEKHA7,LPP

    Protein Function

    LIMA1 has several biochemical functions, for example, actin filament binding,actin monomer binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIMA1 itself. We selected most functions LIMA1 had, and list some proteins which have the same functions with LIMA1. You can find most of the proteins on our site.

    Function Related Protein
    actin filament binding USH1C,MICALL2,AIF1L,TAGLN3B,CORO1CA,GAS2L2,SHROOM2,FSCN1A,FLNC,SMYHC2
    protein binding ABCG8,UBAP2L,CEP350,CD22,TMEM231,SKI,RND1,FBP2,PPM1B,C3orf62
    actin monomer binding PRKCE,ABL1,MYL3,TWF2,MYL2,COBL,MKL1,LMOD3,TMSB,PFN2
    zinc ion binding TRIM3B,CECR1,FHL2,POLE,ESR2,OTUD7A,ZDHHC14,FHL3,FTR54,SIRT3

    Interacting Protein

    LIMA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIMA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIMA1.

    SVIL;YWHAZ;dAK1_1;PLEKHG3;b4e2v5_human;RPSA;midostaurin;DST;PICALM;SEC16A;ACTG1;PDLIM1;MYO1C;MYO1C;PIK3C2A;Flot1;ABLIM1;GAK

    Resources

    References

    • Ohoka, A; Kajita, M; et al. EPLIN is a crucial regulator for extrusion of RasV12-transformed cells. JOURNAL OF CELL SCIENCE 128:781-789(2015).
    • Nie, ZL; Du, MQ; et al. Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma. Nature Communications 6:-(2015).

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