LHX1
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Official Full Name
LIM homeobox 1 -
Overview
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract. -
Synonyms
LHX1;LIM homeobox 1;LIM/homeobox protein Lhx1;LIM 1;LIM1;LIM homeobox protein 1;homeobox protein Lim-1;LIM-1;MGC126723;MGC138141
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LHX1-568H | Recombinant Human LHX1, His-tagged | E.coli | Human | His | C-147aa | |
| LHX1-3669H | Recombinant Human LHX1 protein, GST-tagged | E.coli | Human | GST | 115-180 aa | |
| LHX1-3404R | Recombinant Rat LHX1 Protein | Mammalian Cell | Rat | His |
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| LHX1-6964C | Recombinant Chicken LHX1 | Mammalian Cell | Chicken | His |
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| LHX1-9085M | Recombinant Mouse LHX1 Protein | Mammalian Cell | Mouse | His |
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| LHX1-4752HCL | Recombinant Human LHX1 293 Cell Lysate | HEK293 | Human | Non |
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| LHX1-3060R | Recombinant Rat LHX1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| LHX1-3060R-B | Recombinant Rat LHX1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| LHX1-5073M | Recombinant Mouse LHX1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| LHX1-5073M-B | Recombinant Mouse LHX1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
LHX1 involved in several pathways and played different roles in them. We selected most pathways LHX1 participated on our site, such as Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LHX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neural Crest Differentiation | TFAP2A,DLL3,GBX2,CTBP2,LHX2,PHOX2B,MBP,DCT,MIA,PMP22 |
Protein Function
LHX1 has several biochemical functions, for example, sequence-specific DNA binding,transcription corepressor activity,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LHX1 itself. We selected most functions LHX1 had, and list some proteins which have the same functions with LHX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | CBX4,FOXP3,CREG1,SSX1,FEV,SKIL,YAP1,LDB1,CIR1,YWHAB |
| zinc ion binding | JADE1,TTC3,LIMCH1A,MLL1,KLF4,MYT1,USP44,RBM4B,CXXC4,MARCH6 |
| sequence-specific DNA binding | FOXO1B,WHSC1,ARX,RXRA,NKX2.4B,CAMTA2,LHX1B,GATA2B,SPDEF,ZKSCAN14 |
| transcription factor activity, sequence-specific DNA binding | FLI1B,ZFP1,NKX2-1,L3MBTL1,FOXK2,GATA6,IRF3,NME2,TAL1,RARG |
Interacting Protein
LHX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LHX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LHX1.
Resources
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References
- Makarev, E; Gorivodsky, M; et al. Islet1 and Its Co-Factor Ldb1 Are Expressed in Quiescent Cells of Mouse Intestinal Epithelium. PLOS ONE 9:-(2014).
- Nanez, A; Ramos, IN; et al. A Mutant Ahr Allele Protects the Embryonic Kidney from Hydrocarbon-Induced Deficits in Fetal Programming. ENVIRONMENTAL HEALTH PERSPECTIVES 119:1745-1753(2011).
