LGALS1
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Official Full Name
lectin, galactose binding, soluble 1 -
Overview
Galectin-1 is aprotein that in humans is encoded by the LGALS1 gene. The galectins are afamily of beta-galactoside-binding proteins implicated in modulatingcell-cell and cell-matrix interactions. LGALS1 may act as an autocrinenegative growth factor that regulates cell proliferation. -
Synonyms
Lgals1;lectin,galactose binding, soluble 1;L14;Gal-1;Galbp;L-14.5;Lect14;AA410090;galectin-1;galaptin;14 kDa lectin;S-Lac lectin 1;lactose-binding lectin1;beta-galactoside binding protein;lectin galactoside-binding soluble 1;beta-galactoside-binding lectin L-14-I;GAL1;GBP
Recombinant Proteins
- Mouse
- Human
- Rat
- Rhesus macaque
- Cattle
- Rabbit
- Pig
- Chicken
- Bovine
- E.coli
- HEK293
- Mammalian Cell
- HEK293T
- Mammalian cells
- Non
- GST
- His
- Fc
- His&Fc&Avi
- Myc&DDK
- Flag
- His&SUMO
- His&Myc
Involved Pathway
LGALS1 involved in several pathways and played different roles in them. We selected most pathways LGALS1 participated on our site, such as Validated targets of C-MYC transcriptional repression, which may be useful for your reference. Also, other proteins which involved in the same pathway with LGALS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Validated targets of C-MYC transcriptional repression | TMEFF2,NDRG1,DNTT,S100A7,CSDE1,TMEM126A,CLU,MXD4,GFI1,SFXN3 |
Protein Function
LGALS1 has several biochemical functions, for example, glycoprotein binding,lactose binding,laminin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LGALS1 itself. We selected most functions LGALS1 had, and list some proteins which have the same functions with LGALS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | LGALS6,BMP4,SETMAR,CREB3L3,ACAT1,TARBP2,PTPRE,IRF3,UGT1A1,CBS |
| signal transducer activity | PTH1RA,GPR152,GJA1,SECTM1,PPFIA1,STMN1,OLFR998,PROKR1A,OPN1MW1,OLFR18 |
| poly(A) RNA binding | ENO1,TRMT6,SAP18,MEX3C,TMSB4X,NLRP11,NGRN,DHX35,TMEM38A,EIF4E |
| laminin binding | CTSS,LYPD5,ITGA9,ITGB1,LGALS2A,ECM1,THBS1,BCAM,RPSA,LYPD3 |
| glycoprotein binding | FYN,EDEM1,SERPINA1,RAB14,FBXO17,FBXO6,SELP,DNAJA2,Serpina1b,STX1A |
| protein binding | SERPINI2,ZFP110,NUP155,TRIM40,SCFD1,NLK,GLYCTK,BACE1,HGD,UFL1 |
| lactose binding | LGALS12 |
Interacting Protein
LGALS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LGALS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LGALS1.
ALCAM;KDR;PTPRC;CD6;VCAM1;FLT1;YWHAZ;Trim69;SUSD2;TFAP2A;CDC42
Resources
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References
- Romaniuk, MA; Croci, DO; et al. Binding of galectin-1 to alpha(IIb)beta(3) integrin triggers "outside-in" signals, stimulates platelet activation, and controls primary hemostasis. FASEB JOURNAL 26:2788-2798(2012).
- Perotti, C; Wiedl, T; et al. Characterization of mammary epithelial cell line HC11 using the NIA 15k gene array reveals potential regulators of the undifferentiated and differentiated phenotypes. DIFFERENTIATION 78:269-282(2009).
