LDOC1
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Official Full Name
leucine zipper, down-regulated in cancer 1 -
Overview
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. -
Synonyms
LDOC1;leucine zipper, down-regulated in cancer 1;BCUR1;protein LDOC1;Mar7;Mart7;Breast cancer up regulated 1;Breast cancer upregulated 1;Gm366;Leucine zipper down regulated in cancer 1;Leucine zipper protein down regulated in cancer cells;RGD1565644;OTTHUMP00000024174;breast cancer, up-regulated 1;leucine zipper protein down-regulated in cancer cells
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- His&T7
- Non
- His&GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
LDOC1 involved in several pathways and played different roles in them. We selected most pathways LDOC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LDOC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
LDOC1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LDOC1 itself. We selected most functions LDOC1 had, and list some proteins which have the same functions with LDOC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TNKS,MAP1LC3C,UBE3A,NUMBL,ATM,HNRNPK,PWWP2B,SPRED1,BECN1,FBL |
Interacting Protein
LDOC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LDOC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LDOC1.
PSMA1;HGS;DPPA4;ATF4;FOSL1
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References
