LBR
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Official Full Name
lamin B receptor -
Overview
The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] -
Synonyms
LBR;lamin B receptor;PHA;LMN2R;TDRD18;DHCR14B;lamin-B receptor;tudor domain containing 18;integral nuclear envelope inner membrane protein
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- His
- Non
- His&Fc&Avi
Involved Pathway
LBR involved in several pathways and played different roles in them. We selected most pathways LBR participated on our site, such as Cholesterol biosynthesis,Gastric cancer network 2,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LBR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cholesterol biosynthesis I | DHCR7,DHCR24,EBP |
| Gastric cancer network 2 | MTDH,RNF144B,BRIX1,CHTF18,PLAC8,RAD17,CHTF8,DSCC1,TOP2A,SNURF |
| Cholesterol biosynthesis | CYP51A1,SREBF2,PMVK,EBP,DHCR7,ARV1,DHCR24 |
| cholesterol biosynthesis II (via 24,25-dihydrolanosterol) | EBP,DHCR24 |
| Metabolism of lipids and lipoproteins | ACOT11B,NFYBB,FABP9,MED16,CYP24A1,MED20,ACOT9,FA2H,GLIPR1,TMEM195 |
| cholesterol biosynthesis III (via desmosterol) | EBP |
| Metabolism | BHMT2,NDUFAF4,CTGF,COX5B,BCHE,SULT1C4,MED16,NAMPT,UROC1,MARCKSB |
Protein Function
LBR has several biochemical functions, for example, DNA binding,chromo shadow domain binding,lamin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LBR itself. We selected most functions LBR had, and list some proteins which have the same functions with LBR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | ZFP36L1,QKI,YTHDF2,RPL4,PFN1,TRMT1,MFAP1,GFM1,SLTM,RPS15A |
| chromo shadow domain binding | ATRX,NIPBL,TRIM28,CHAF1A,SP100 |
| protein binding | HHLA3,MYH11,PAAF1,ASCL3,PACSIN2,ZNF567,MXI1,MDFIC,CEP350,HPS6 |
| lamin binding | PPP4C,SUN1,SUN2,IFI27,TMEM201,TOR1AIP1,SYNE1,BNIP3L,NARF,TMPO |
| oxidoreductase activity, acting on the CH-CH group of donors | SRD5A2A,TECR,TECRL,GCDHB,ACOXL,PPP1R2,TECRL2B,TM7SF2,SRD5A3,DPYDB |
| oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | SRD5A3,DHCR24,BDH2,TM7SF2 |
| DNA binding | LEF1,ORC1L,THAP3,ZNF350,ZNF710,HIST2H2BB,DLX4B,TOX2,ZFP239,ZNF496 |
Interacting Protein
LBR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LBR here. Most of them are supplied by our site. Hope this information will be useful for your research of LBR.
CBX3;CBX5;YWHAG;SRPK1;7242199;MYC;YWHAB;PHLDA3;E2F3;ARRB2;CLK3;LRRK2
Resources
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References
- Goans, RE; Iddins, CJ; et al. APPEARANCE OF PSEUDO-PELGER HUET ANOMALY AFTER ACCIDENTAL EXPOSURE TO IONIZING RADIATION IN VIVO. HEALTH PHYSICS 108:303-307(2015).
- Cicinelli, E; Matteo, M; et al. Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. HUMAN REPRODUCTION 30:323-330(2015).
