LATS1
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Official Full Name
LATS, large tumor suppressor, homolog 1 -
Overview
LATS1 (Large tumor suppressor 1) is a putative serine/threonine kinase that belongs to the NDR family. It is a tumor suppressor that plays a critical role in the maintenance of ploidy. LATS1 localizes to the centrosome and the mitotic spindle and controls -
Synonyms
LATS1;LATS, large tumor suppressor, homolog 1 (Drosophila);LATS (large tumor suppressor, Drosophila) homolog 1;serine/threonine-protein kinase LATS1;WARTS;h-warts;WARTS protein kinase;large tumor suppressor homolog 1;wts
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Sf9 Cells
- Mammalian Cells
- HEK293
- E.coli
- GST
- His
- Non
- Avi&Fc&His
- His&Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LATS1-1423H |
Active Recombinant Human LATS1, GST-tagged
|
Sf9 Cells | Human | GST | 589 aa-end |
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| LATS1-2707Z | Recombinant Zebrafish LATS1 | Mammalian Cells | Zebrafish | His |
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| LATS1-8971M | Recombinant Mouse LATS1 Protein | Mammalian Cells | Mouse | His |
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| LATS1-974HCL | Recombinant Human LATS1 cell lysate | Human | Non |
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| LATS1-5003M | Recombinant Mouse LATS1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| LATS1-5003M-B | Recombinant Mouse LATS1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| LATS1-5356H | Recombinant Human LATS1 protein, His&Myc-tagged | E.coli | Human | His&Myc | 705-1090aa |
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Involved Pathway
LATS1 involved in several pathways and played different roles in them. We selected most pathways LATS1 participated on our site, such as Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LATS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hippo signaling pathway | BBC3,JUB,SMAD3,WNT1,WNT3,WNT2B,LLGL1,WWTR1,PPP2R2A,WWC1 |
Protein Function
LATS1 has several biochemical functions, for example, ATP binding,magnesium ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LATS1 itself. We selected most functions LATS1 had, and list some proteins which have the same functions with LATS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CDKL5,BAT1,CLPXA,SMC5,KTI12,TTLL3,HSPA7,ABCC11,NLRP9B,SNRK |
| magnesium ion binding | CERK,CLYBL,S100P,SNCA,FIGNL1,ATP11A,IDH1,TSSK6,ZAK,SERPINB1A |
| protein binding | CTNNB1,CHRD,TAX1BP1,IMPDH2,TEAD1,IL5,TRIM50,MRPS31,MAPK14,CENPA |
| protein kinase binding | TSACC,NBEA,BORA,SPRY2,GHR,NCS1,SUFU,IKBKB,H2AFY,PTPRR |
| protein serine/threonine kinase activity | GRK1B,PKMYT1,SRPK1,CAMKK1A,PKN1B,CDC42BPG,MARK3,MARK1,DAPK1,SBK1 |
Interacting Protein
LATS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LATS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LATS1.
YAP1;MOB1B;MOB1A
Resources
Related Services
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References
- Meistermann, H; Gao, JJ; et al. A Novel Immuno-Competitive Capture Mass Spectrometry Strategy for Protein-Protein Interaction Profiling Reveals That LATS Kinases Regulate HCV Replication Through NS5A Phosphorylation. MOLECULAR & CELLULAR PROTEOMICS 13:3040-3048(2014).
- Chan, SW; Lim, CJ; et al. Actin-binding and Cell Proliferation Activities of Angiomotin Family Members Are Regulated by Hippo Pathway-mediated Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 288:37296-37307(2013).
