LASS4
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Official Full Name
ceramide synthase 4 -
Overview
Ceramide synthase 4 (CerS4) is an enzyme that in humans is encoded by the CERS4 gene and is one of the least studied of the ceramide synthases. -
Synonyms
LAG1 homolog, ceramide synthase 4;CerS4;FLJ12089;Trh1;LAG1 longevity assurance homolog 4 (S. cerevisiae);LAG1 longevity assurance homolog 4;LASS4;ceramide synthase 4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LASS4-8966M | Recombinant Mouse LASS4 Protein | Mammalian Cell | Mouse | His |
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| LASS4-5000M | Recombinant Mouse LASS4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| LASS4-5000M-B | Recombinant Mouse LASS4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
LASS4 involved in several pathways and played different roles in them. We selected most pathways LASS4 participated on our site, such as Sphingolipid metabolism,Metabolic pathways,Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LASS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ackA,TPK1,ATP5A1,COX4I2,ADH1,PIGH,IDH3A,CYP3A25,PON2,MTMR4 |
| Sphingolipid metabolism | ASAH1A,SGPP2,CERS2,OSBP,ASAH2,SPTLC3,ASAH1,GBA,SPTLC1,SMPD3 |
| Sphingolipid signaling pathway | AKT2,MAPK8,PTEN,PDPK1,MAPK10,NFKB1,FYN,RHOA,PPP2R2A,PRKCE |
Protein Function
LASS4 has several biochemical functions, for example, DNA binding,sphingosine N-acyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LASS4 itself. We selected most functions LASS4 had, and list some proteins which have the same functions with LASS4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sphingosine N-acyltransferase activity | CERS2,CERS4A,CERS4,LASS5,LASS1,LASS2,CERS2A,FAM57B,CERS5,CERS3B |
| DNA binding | ZNF45,ZNF781,NKX6.1,TERFA,FOXJ1A,ZNF697,PA2G4,E2F5,HIST2H2BB,POT1A |
Interacting Protein
LASS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LASS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of LASS4.
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References
- Ebel, P; Imgrund, S; et al. Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia. BIOCHEMICAL JOURNAL 461:147-158(2014).
- Haller, JF; Cavallaro, P; et al. Endogenous beta-glucocerebrosidase activity in Abca12(-/-) epidermis elevates ceramide levels after topical lipid application but does not restore barrier function. JOURNAL OF LIPID RESEARCH 55:493-503(2014).
