LASS1
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Official Full Name
LAG1 homolog, ceramide synthase 1 -
Overview
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. -
Synonyms
LAG1 homolog, ceramide synthase 1;Protein UOG-1;UOG1;LAG1 longevity assurance homolog 1 (S. cerevisiae);LAG1;MGC90349;CerS1;LAG1 longevity assurance homolog 1;longevity assurance (LAG1, S. cerevisiae) homolog 1;upstream of GDF1;Longevity assurance gene 1 protein homolog 1;LASS1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LASS1-8964M | Recombinant Mouse LASS1 Protein | Mammalian Cell | Mouse | His |
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| LASS1-4998M | Recombinant Mouse LASS1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| LASS1-4998M-B | Recombinant Mouse LASS1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
LASS1 involved in several pathways and played different roles in them. We selected most pathways LASS1 participated on our site, such as Sphingolipid metabolism,Metabolic pathways,Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LASS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid signaling pathway | SPTLC2,FCER1G,PLCB1,PPP2R1B,PLD1,BID,PPP2R2A,PPP2R5C,CERS2,S1PR5 |
| Sphingolipid metabolism | ARSK,PPM1LB,CERS2,R05D11.9,VAPB,SMPD5,LASS5,PPM1LA,DEGS1,ARSA |
| Metabolic pathways | LAP3,POLR2C,MTMR1,CYP21A1,AHCY,PTGIS,ACSBG2,CYP24A1,KLF15,NDUFA8 |
Protein Function
LASS1 has several biochemical functions, for example, sphingosine N-acyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LASS1 itself. We selected most functions LASS1 had, and list some proteins which have the same functions with LASS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sphingosine N-acyltransferase activity | CERS5,LASS2,CERS3B,LASS5,FAM57B,CERS2A,LASS4,CERS2,CERS4A,CERS4 |
Interacting Protein
LASS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LASS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LASS1.
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References
- Derer, S; Till, A; et al. mTNF reverse signalling induced by TNF alpha antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease. GUT 62:376-386(2013).
- Zhao, QH; Wang, HF; et al. Expression of a tumor-associated gene, LASS2, in the human bladder carcinoma cell lines BIU-87, T24, EJ and EJ-M3. EXPERIMENTAL AND THERAPEUTIC MEDICINE 5:942-946(2013).
