LARS2
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Official Full Name
leucyl-tRNA synthetase 2, mitochondrial -
Overview
This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. -
Synonyms
LARS2;leucyl-tRNA synthetase 2, mitochondrial;probable leucyl-tRNA synthetase, mitochondrial;KIAA0028;leucine tRNA ligase 2;mitocondrial;LEURS;MGC26121;mitochondrial;LARS 2;Leucine translase;Leucine tRNA ligase 2 mitocondrial;Leucine tRNA ligase;Leucine--tRNA ligase;Leucyl tRNA synthetase 2;Leucyl tRNA synthetase 2 mitochondrial;Probable leucyl-tRNA synthetase;SYLM_HUMAN;OTTHUMP00000164232;OTTHUMP00000210279;OTTHUMP00000210280;leucine tRNA ligase 2, mitocondrial
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LARS2-510H | Recombinant Human LARS2, GST-tagged | E.coli | Human | GST | 554-903aa | |
| LARS2-6037Z | Recombinant Zebrafish LARS2 | Mammalian Cell | Zebrafish | His |
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| LARS2-8961M | Recombinant Mouse LARS2 Protein | Mammalian Cell | Mouse | His |
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| LARS2-972HCL | Recombinant Human LARS2 cell lysate | Human | Non |
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| Lars2-1731M | Recombinant Mouse Lars2 Protein, His-tagged | E.coli | Mouse | His | Gln609-Glu902 |
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| LARS2-2385H | Recombinant Human LARS2 Protein, His-tagged | E.coli | Human | His | Leu677-Asp903 |
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| LARS2-4996M | Recombinant Mouse LARS2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| LARS2-4996M-B | Recombinant Mouse LARS2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
LARS2 involved in several pathways and played different roles in them. We selected most pathways LARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with LARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aminoacyl-tRNA biosynthesis | EPRS,FARSB,MADD,MTFMT,DARS,KARS,TARSL2,PSTK,VARS,PET112L |
Protein Function
LARS2 has several biochemical functions, for example, ATP binding,aminoacyl-tRNA editing activity,leucine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LARS2 itself. We selected most functions LARS2 had, and list some proteins which have the same functions with LARS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aminoacyl-tRNA editing activity | IARS,AARS,PRORSD1,VARS2,VARS,DTD1,IARS2,LARS,DTD2 |
| leucine-tRNA ligase activity | LARS |
| ATP binding | STK32B,GLULB,PAK1,XYLB,P2RY2,MAP3K3,DHX8,TBCK,MCCC2,CDK3 |
Interacting Protein
LARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LARS2.
Resources
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References
- Pierce, SB; Gersak, K; et al. Mutations in LARS2, Encoding Mitochondrial Leucyl-tRNA Synthetase, Lead to Premature Ovarian Failure and Hearing Loss in Perrault Syndrome. AMERICAN JOURNAL OF HUMAN GENETICS 92:614-620(2013).
- Li, RH; Guan, MX; et al. Human Mitochondrial Leucyl-tRNA Synthetase Corrects Mitochondrial Dysfunctions Due to the tRNA(Leu(UUR)) A3243G Mutation, Associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Symptoms and Diabetes. MOLECULAR AND CELLULAR BIOLOGY 30:2147-2154(2010).
