LARS
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Official Full Name
leucyl-tRNA synthetase -
Overview
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known. -
Synonyms
LARS;leucyl-tRNA synthetase;leucyl-tRNA synthetase, cytoplasmic;FLJ10595;FLJ21788;HSPC192;LARS1;leucine tRNA ligase 1;cytoplasmic;LEUS;RNTLS;Leucine tRNA ligase;Cytoplasmic leucyl tRNA synthetase;Cytosolic leucyl tRNA synthetase;hr025Cl;HSPC 192;KIAA1352;LARS 1;Leucine translase;Leucyl tRNA synthetase cytoplasmic;LeuRS;LRS;PIG 44;PIG44;Proliferation inducing gene 44;OTTHUMP00000223912;OTTHUMP00000223913;leucine-tRNA ligase;leucine--tRNA ligase;proliferation-inducing gene 44;cytosolic leucyl-tRNA synthetase;cytoplasmic leucyl-tRNA synthetase;leucine tRNA ligase 1, cytoplasmic
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LARS-509H | Recombinant Human LARS, GST-tagged | E.coli | Human | GST | C-350aa | |
| LARS-262H | Recombinant Human LARS | Mammalian Cell | Human | His |
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| LARS-8208H | Recombinant Human LARS protein, His & T7-tagged | E.coli | Human | His&T7 | Gly260~Glu509 |
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| Lars-1730M | Recombinant Mouse Lars Protein, His&GST-tagged | E.coli | Mouse | His&GST | Met1-Ala321 |
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| LARS-3336H | Recombinant Human LARS Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| LARS-3336H-B | Recombinant Human LARS Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
LARS involved in several pathways and played different roles in them. We selected most pathways LARS participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with LARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aminoacyl-tRNA biosynthesis | EARS2,HARS2,YARS2,AARS2,GATC,IARS,CARS,WARS,PSTK,VARS |
Protein Function
LARS has several biochemical functions, for example, ATP binding,aminoacyl-tRNA editing activity,leucine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LARS itself. We selected most functions LARS had, and list some proteins which have the same functions with LARS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aminoacyl-tRNA editing activity | PRORSD1,VARS2,VARS,LARS2,AARS,IARS,DTD1,DTD2,IARS2 |
| ATP binding | UBE2L3A,CLCN4-2,WARS2,MYH8,Fert2,ABCA8,EIF4A2,AKT3A,DNAJA2L,STK17A |
| leucine-tRNA ligase activity | LARS2 |
| protein binding | ZBTB17,SRA1,IRF2,LRFN2,PARVA,DDR2,WDFY3,Icosl,VAV1,KDM5A |
| NOT methionine-tRNA ligase activity | AIMP1 |
Interacting Protein
LARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LARS here. Most of them are supplied by our site. Hope this information will be useful for your research of LARS.
RRAGD;RARS;RPTOR;gag
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References
- Ma, LL; O'Byrne, PM; et al. The pharmacological modulation of allergen-induced asthma. INFLAMMOPHARMACOLOGY 21:113-124(2013).
- Muller, A; Lehmann, I; et al. Increased incidence of allergic sensitisation and respiratory diseases due to mould exposure: Results of the Leipzig Allergy Risk children Study (LARS). INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 204:363-365(2002).
